Article information
Abstract
Objective
To estimate an accurate level of IL-8 in aqueous humor among open-angle glaucoma (OAG) patients.
MethodsMeta-analysis was performed from available studies that investigated the IL-8 level in the aqueous humor of OAG patients and control subjects.
ResultsA total of 17 studies were selected. The pooled result showed that IL-8 levels in aqueous humor of patients with OAG were higher than in control subjects (SMD = 0.98, 95 % CI = 0.68–1.27, p < 0.00001).
ConclusionThis meta-analysis indicates that patients with OAG may have higher aqueous humor IL-8 levels compared to control subjects, which supports the notion that IL-8 is one of the contributing factors in the development of OAG.
Keywords:
Chemokine
IL-8
Open-angle glaucoma (OAG)
Resumen
Objetivo
Estimar un nivel preciso de IL-8 en humor acuoso en pacientes con glaucoma de ángulo abierto (GAA).
MétodosSe realizó un metanálisis a partir de los estudios disponibles que investigaron el nivel de IL-8 en el humor acuoso de pacientes con GAA y sujetos de control.
ResultadosSe seleccionó un total de 17 estudios. El resultado agrupado mostró que los niveles de IL-8 en el humor acuoso de los pacientes con GAA fueron mayores que en los sujetos de control (DME = 0,98; IC del 95 %: 0,68 a 1,27; p < 0,00001.
ConclusiónEste meta-análisis indica que los pacientes con GAA pueden tener un humor acuoso de IL-8 más alto en comparación con los sujetos de control, lo que apoya la noción de que la IL-8 es uno de los factores contribuyentes en el desarrollo del GAA.
Palabras clave:
Quimioquina
IL-8
Glaucoma de ángulo abierto (GAA)
Article
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