Article information
Abstract
The use of amniotic membrane (AM) in ophthalmology has been increasing in recent years due to its multiple biological and tectonic properties, improvement in the process of obtaining, ease of use, and advancement in tissue engineering. The AM has become one of the main adjuvant treatments, in ophthalmic surgery as well as in other medical-surgical specialties. The development of tissue engineering has allowed it to be used, not only in its classic form, but also by the use of drops and other presentations. The different steps prior to its use (preparation and conservation), the different surgical techniques, and their main clinical applications are described throughout the article.
Keywords:
Amniotic membrane
Tissue engineering
Cornea
Ocular surface
Resumen
La utilización de la membrana amniótica (MA) en la oftalmología está en alza en los últimos años debido a sus múltiples propiedades biológicas y tectónicas, la mejora en el proceso de obtención, la facilidad de uso y el avance en la ingeniería tisular. La MA se ha convertido en uno de los principales tratamientos coadyuvantes, tanto en la cirugía oftalmológica como en otras especialidades médico-quirúrgicas. El desarrollo de la ingeniería tisular ha permitido su utilización no solo en su forma clásica sino también mediante gotas y otras presentaciones. A lo largo del articulo hemos realizado un resumen de los distintos pasos previo a su uso (preparación y conservación), las distintas técnicas quirúrgicas y sus principales aplicaciones clínicas.
Palabras clave:
Membrana amniótica
Ingeniería tisular
Córnea
Superficie ocular
Article
These are the options to access the full texts of the publication Archivos de la Sociedad Española de Oftalmología (English Edition)
Subscriber
Purchase
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
References
[1]
J.W. D.
Skin transplantation with a review of 550 cases at the Johns Hopkins hospital.
Johns Hopkins Med J., 15 (1910), pp. 307-396
[2]
M.S. Murri, M. Moshirfar, O.C. Birdsong, Y. Ronquillo, Y. Ding, P.C. Hoopes.
Amniotic membrane extract and eye drops: a review of literature and clinical application.
Clin Ophthalmol [Internet], 12 (2018), pp. 1105-1112
[3]
A. De Rotth.
Plastic repair of conjunctival defects with fetal membranes.
Arch Ophthalmol [Internet], 23 (1940), pp. 522-525
[4]
T. John.
Human amniotic membrane transplantation: past, present, and future.
Ophthalmol Clin North Am [Internet], 16 (2003), pp. 43-65
[5]
J.F. Batlle, F.J. Perdomo.
Placental membranes as a conjunctival substitute.
Ophthalmol., 100 (1993), pp. A107
[6]
J. Alemañy González, F. Camacho Ruaigip.
Usos de la membrana amniótica humana en oftalmología.
Rev Cuba Oftalmol., 19 (2006), pp. 1-7
[7]
J.M. Ortega-molina, H.S. Agustin, A.D.E. Revisión.
La membrana amniótica en oftalmología: del recubrimiento-injerto a la ingeniería tisular. Artículo de revisión. Rev española Investig oftalmológicas.
Rev Esp Inv Oftal, IV (2014), pp. 117-122
[8]
Sabater AL, Perez VL. Amniotic membrane use for management of corneal limbal stem cell deficiency. [cited 2018 Jun 3]; Available from: https://insights.ovid.com/pubmed?pmid=28426442.
[9]
J.C. Kim, S.C. Tseng.
Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas.
Cornea [Internet], 14 (1995), pp. 473-484
[10]
M. Kobayashi, T. Yakuwa, K. Sasaki, K. Sato, A. Kikuchi, I. Kamo, et al.
Multilineage potential of side population cells from human amnion mesenchymal layer.
Cell Transplant [Internet], 17 (2008), pp. 291-301
[11]
M. Hasegawa, H. Fujisawa, Y. Hayashi, J. Yamashita.
Autologous amnion graft for repair of myelomeningocele: technical note and clinical implication.
J Clin Neurosci [Internet], 11 (2004), pp. 408-411
[12]
P. Favaron, R. Carvalho, J. Borghesi, A. Anunciação, M. Miglino.
The Amniotic Membrane: Development and Potential Applications - A Review.
Reprod Domest Anim [Internet], 50 (2015), pp. 881-892
[13]
B.J. van Herendael, C. Oberti, I. Brosens.
Microanatomy of the human amniotic membranes: A light microscopic, transmission, and scanning electron microscopic study.
Am J Obstet Gynecol [Internet], 131 (1978), pp. 872-880
[14]
Ginel, M.I. Gascon.
Desarrollo del sistema de cohesion intercelular en el epitelio corneal humano generado por ingenieria tisular. Estudio genetico e histologico.
(2008),
[15]
C. Malhotra, A.K. Jain.
Human amniotic membrane transplantation: Different modalities of its use in ophthalmology.
World J Transplant [Internet], 4 (2014), pp. 111-121
[16]
T.P. Utheim, Ø Aass Utheim, P. Salvanos, C.J. Jackson, S. Schrader, G. Geerling, et al.
Concise Review: Altered Versus Unaltered Amniotic Membrane as a Substrate for Limbal Epithelial Cells.
Stem Cells Transl Med [Internet], 7 (2018), pp. 415-427
[17]
M. Litwiniuk, T. Grzela.
Amniotic membrane: New concepts for an old dressing.
Wound Repair Regen [Internet], 22 (2014), pp. 451-456
[18]
P. Chiaradia, A. Tytiun, M.J. Botta, S. Albornoz, L. Huarte, L. Abuin.
Uso de membrana amniótica en reconstrucción de superficie ocular: resultados preliminares.
Oftalmol Clin Exp (ISSN 1851-2658), 4 (2010), pp. 64-68
[19]
G.S. Noureddin, S.N. Yeung.
The use of dry amniotic membrane in pterygium surgery.
Clin Ophthalmol [Internet], 10 (2016), pp. 705-712
[20]
N. Sharma, M. Kaur, T. Agarwal, V.S. Sangwan, R.B. Vajpayee.
Treatment of acute ocular chemical burns.
Surv Ophthalmol [Internet], 63 (2018), pp. 214-235
[21]
J. Lacorzana-Rodríguez, J.L. García-Serrano, C. Gálvez Prieto-Moreno, S. Castillo-Rodríguez, J.A. Lucena-Martín, I. Pozo-Jiménez.
Amniotic membrane, review of its ophthalmic use and results in the last five years (2013-2017) in Granada. Preliminary study.
Actual Medica [Internet], 103 (2018), pp. 82-86
[22]
K. Akazawa, K. Iwasaki, M. Nagata, N. Yokoyama, H. Ayame, K. Yamaki, et al.
Cell transfer technology for tissue engineering.
Inflamm Regen [Internet], 37 (2017), pp. 21
[23]
Ö Barut Selver, A. Yağcı, S. Eğrilmez, M. Gürdal, M. Palamar, T. Çavuşoğlu, et al.
Limbal Stem Cell Deficiency and Treatment with Stem Cell Transplantation.
Turkish J Ophthalmol [Internet], 47 (2017), pp. 285-291
[24]
M.D. Resch, U. Schlötzer-Schrehardt, C. Hofmann-Rummelt, R. Sauer, F.E. Kruse, M.W. Beckmann, et al.
Integration Patterns of Cryopreserved Amniotic Membranes into the Human Cornea.
Ophthalmology [Internet], 113 (2006), pp. 1927-1935
[25]
M.D. Resch, U. Schlo¨tzer-Schrehardt, C. Hofmann-Rummelt, R. Sauer, C. Cursiefen, F.E. Kruse, et al.
Adhesion Structures of Amniotic Membranes Integrated into Human Corneas.
Investig Opthalmology Vis Sci [Internet], 47 (2006), pp. 1853
[26]
O.O. Uçakhan, G. Köklü, E. Firat.
Nonpreserved human amniotic membrane transplantation in acute and chronic chemical eye injuries.
Cornea [Internet], 21 (2002), pp. 169-172
[27]
R. Arora, D. Mehta, V. Jain.
Amniotic membrane transplantation in acute chemical burns.
Eye (Lond) [Internet], 19 (2005), pp. 273-278
[28]
L.F. Mejía, C. Acosta, J.P. Santamaría.
Use of nonpreserved human amniotic membrane for the reconstruction of the ocular surface.
Cornea [Internet], 19 (2000), pp. 288-291
[29]
G. Mart, D.E.B. Redondo, G. Santana.
Transplante de membrana amniótica en patología de la superficie ocular Amniotic membrane trasplantation in ocular surface patology.
(2001), pp. 1-7
[30]
M.T. Rodríguez-Ares, M.J. López-Valladares, R. Touriño, B. Vieites, F. Gude, M.T. Silva, et al.
Effects of lyophilization on human amniotic membrane.
Acta Ophthalmol [Internet], 87 (2009), pp. 396-403
[31]
H.S. Dua, D.G. Said, E.M. Messmer, M. Rolando, J.M. Benitez-del-Castillo, P.N. Hossain, et al.
Neuropathic keratopathy.
Prog Retin Eye Res [Internet], (2018),
[32]
Lee, S.C.G. Shwu-Huey Tseng.
Amniotic Membrane Transplantation for Persistent Epithelial Defects With Ulceration.
Am J Ophthalmol [Internet], 123 (1997), pp. 303-312
[33]
C. Chirapapaisan, P. Prabhasawat, S. Srivannaboon, V. Roongpoovapatr, P. Chitsuthipakorn.
Ocular Injury due to Potassium Permanganate Granules.
Case Rep Ophthalmol [Internet], 9 (2018), pp. 132-137
[34]
L. Thomas, M. Weng, R. Schulze, J. Bromley, S. Thacker.
Ophthalmic Considerations in Stevens-Johnson Syndrome.
J Pediatr [Internet], 175 (2016), pp. 235
[35]
K. Suri, M. Kosker, I.M. Raber, K.M. Hammersmith, P.K. Nagra, B.D. Ayres, et al.
Sutureless amniotic membrane ProKera for ocular surface disorders: short-term results.
Eye Contact Lens [Internet], 39 (2013), pp. 341-347
[36]
I. Kotomin, M. Valtink, K. Hofmann, A. Frenzel, H. Morawietz, C. Werner, et al.
Sutureless Fixation of Amniotic Membrane for Therapy of Ocular Surface Disorders. Taylor AW, editor.
PLoS One [Internet], 10 (2015),
[37]
E. Costa, J.N. Murta.
Amniotic Membrane in Ophthalmology.
Amniotic Membrane [Internet], Springer Netherlands, (2015),
[38]
J. Fan, M. Wang, F. Zhong.
Improvement of Amniotic Membrane Method for the Treatment of Corneal Perforation.
Biomed Res Int [Internet], 2016 (2016),
[39]
Z.G.O. del Campo.
Aplicaciones de la membrana amniótica en patología ocular.
Annals d’Oftalmologia., 10 (2002), pp. 128-141
[40]
M. Palamar, E. Kaya, S. Egrilmez, T. Akalin, A. Yagci.
Amniotic membrane transplantation in surgical management of ocular surface squamous neoplasias: long-term results.
Eye (Lond) [Internet], 28 (2014), pp. 1131-1135
[41]
D.F. Anderson, P. Prabhasawat, E. Alfonso, S.C. Tseng.
Amniotic membrane transplantation after the primary surgical management of band keratopathy.
Cornea [Internet], 20 (2001), pp. 354-361
[42]
S. Srinivas, E. Mavrikakis, C. Jenkins.
Amniotic membrane transplantation for painful bullous keratopathy.
Eur J Ophthalmol [Internet], 17 (2018), pp. 7-10
[43]
J. Liu, H. Sheha, Y. Fu, L. Liang, S.C. Tseng.
Update on amniotic membrane transplantation.
Expert Rev Ophthalmol [Internet], 5 (2010), pp. 645-661
[44]
D.G. Gregory.
New Grading System and Treatment Guidelines for the Acute Ocular Manifestations of Stevens-Johnson Syndrome.
Ophthalmology [Internet], 123 (2016), pp. 1653-1658
[45]
D.G. Gregory.
Treatment of Acute Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Using Amniotic Membrane: A Review of 10 Consecutive Cases.
Ophthalmology [Internet], 118 (2011), pp. 908-914
[46]
Ciralsky JB, Sippel KC, Gregory DG. Current ophthalmologic treatment strategies for acute and chronic Stevens-Johnson syndrome and toxic epidermal necrolysis. [cited 2018 Jun 3]; Available from: https://insights.ovid.com/pubmed?pmid=23680755.
[47]
S. Kohanim, S. Palioura, H.N. Saeed, E.K. Akpek, G. Amescua, S. Basu, et al.
Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis – A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease.
Ocul Surf [Internet], 14 (2016), pp. 168-188
[48]
E. Shay, A. Kheirkhah, L. Liang, H. Sheha, D.G. Gregory, S.C.G. Tseng.
Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis.
Surv Ophthalmol [Internet], 54 (2009), pp. 686-696
[49]
H. Westekemper, F.C. Figueiredo, W.F. Siah, N. Wagner, K.-P. Steuhl, D. Meller.
Clinical outcomes of amniotic membrane transplantation in the management of acute ocular chemical injury.
Br J Ophthalmol [Internet], 101 (2017), pp. 103-107
[50]
B. Seitz, S. Das, R. Sauer, et al.
Simultaneous amnioticmembrane patch in high- risk keratoplasty.
Cornea, 30 (2011), pp. 269-272
[51]
A. Joseph, H.S. Dua, A.J. King.
Failure of amniotic membrane transplantation in the treatment of acute ocular burns.
Br J Ophthalmol [Internet], 85 (2001), pp. 1065-1069
[52]
A. Navas, F.S. Magaña-Guerrero, A. Domínguez-López, C. Chávez-García, G. Partido, E.O. Graue-Hernández, et al.
Anti-Inflammatory and Anti-Fibrotic Effects of Human Amniotic Membrane Mesenchymal Stem Cells and Their Potential in Corneal Repair.
Stem Cells Transl Med [Internet], (2018),
[53]
N. Sharma, D. Singh, P.K. Maharana, A. Kriplani, T. Velpandian, R.M. Pandey, et al.
Comparison of Amniotic Membrane Transplantation and Umbilical Cord Serum in Acute Ocular Chemical Burns: A Randomized Controlled Trial.
Am J Ophthalmol [Internet], 168 (2016), pp. 157-163
[54]
Y. Chen, X. Yan, H. Wu, B. Rong.
[An experimental study on the fate of the amniotic membrane after amniotic membrane transplantation for acute alkaline burn of rat cornea].
Zhonghua Yan Ke Za Zhi [Internet], 48 (2012), pp. 27-32
[55]
P. Rama, S. Matuska, G. Paganoni, A. Spinelli, M. De Luca, G. Pellegrini.
Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration.
N Engl J Med [Internet], 363 (2010), pp. 147-155
[56]
A. Marmalidou, A. Kheirkhah, R. Dana.
Conjunctivochalasis: a systematic review.
Surv Ophthalmol [Internet], (2017),
[57]
F.E. Kruse, K. Rohrschneider, H.E. Völcker.
Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers.
Ophthalmology [Internet], 106 (1999), pp. 1504-1511
[58]
H.J. Chen, R.T.F. Pires, S.C.G. Tseng.
Amniotic membrane transplantation for severe neurotrophic corneal ulcers.
Br J Ophthalmol [Internet], 84 (2000), pp. 826-833
[59]
H. Sheha, L. Liang, J. Li, S.C.G. Tseng.
Sutureless amniotic membrane transplantation for severe bacterial keratitis.
Cornea [Internet], 28 (2009), pp. 1118-1123
[60]
S. Mohan, I. Budhiraja, A. Saxena, P. Khan, S.K. Sachan.
Role of multilayered amniotic membrane transplantation for the treatment of resistant corneal ulcers in North India.
Int Ophthalmol [Internet], 34 (2014), pp. 485-491
[61]
M.C. Robson, T.J. Krizek.
The effect of human amniotic membranes on the bacteria population of infected rat burns.
Ann Surg [Internet], 177 (1973), pp. 144
[62]
V. Jhanji, A.L. Young, J.S. Mehta, N. Sharma, T. Agarwal, R.B. Vajpayee.
Management of corneal perforation.
Surv Ophthalmol [Internet], 56 (2011), pp. 522-538
[63]
P. Prabhasawat, N. Tesavibul, W. Komolsuradej.
Single and multilayer amniotic membrane transplantation for persistent corneal epithelial defect with and without stromal thinning and perforation.
Br J Ophthalmol [Internet], 85 (2001), pp. 1455-1463
[64]
M. Teresa Rodríguez-Ares, R. Touriño, M. Jesús López-Valladares, F. Gude.
Multilayer Amniotic Membrane Transplantation in the Treatment of Corneal Perforations [Internet].
(2004),
[65]
G. Savino, D. Colucci, M.I. Giannico, T. Salgarello.
Amniotic membrane transplantation associated with a corneal patch in a paediatric corneal perforation.
Acta Ophthalmol [Internet], 88 (2010), pp. e15-6
[66]
H.-T. Xie, D. Zhao, Y. Liu, M.-C. Zhang.
Umbilical Cord Patch Transplantation for Corneal Perforations and Descemetoceles.
J Ophthalmol [Internet], 2017 (2017), pp. 1-7
[67]
K. Droutsas, D. Papaconstantinou, I. Georgalas, G. Kymionis, K. Andreanos, E. Stamou, et al.
Equine pericardium for tectonic globe repair.
Int Ophthalmol [Internet], (2017),
[68]
R. Cañones-Zafra, J. Benítez-Herreros, K. Kubiak, M.A. Montes-Mollón, R. Jiménez-Parras.
Perforación corneal no traumática estéril tratada con Tachosil®.
Arch Soc Esp Oftalmol [Internet], 86 (2011), pp. 264-266
[69]
A.E. Grau, J.A. Durán.
Treatment of a Large Corneal Perforation With a Multilayer of Amniotic Membrane and TachoSil.
Cornea [Internet], 31 (2012), pp. 98-100
[70]
M.S. Abd Elaziz, A.G. Zaky, A.R. El SaebaySarhan.
Stromal lenticule transplantation for management of corneal perforations; one year results.
Graefe’s Arch Clin Exp Ophthalmol [Internet], 255 (2017), pp. 1179-1184
[71]
S. Hick, P.E. Demers, I. Brunette, C. La, M. Mabon, B. Duchesne.
Amniotic Membrane Transplantation and Fibrin Glue in the Management of Corneal Ulcers and Perforations.
Cornea [Internet], 24 (2005), pp. 369-377
[72]
J. Celis, D. Mesa, E. Avendaño, F. González-Valle.
Adhesivo de fibrina intracameral como tratamiento de perforación corneal espontánea.
Arch Soc Esp Oftalmol [Internet], 89 (2014), pp. 124-126
[73]
R.T. Pires, S.C. Tseng, P. Prabhasawat, V. Puangsricharern, S.L. Maskin, J.C. Kim, et al.
Amniotic membrane transplantation for symptomatic bullous keratopathy.
Arch Ophthalmol (Chicago, Ill 1960) [Internet], 117 (1999), pp. 1291-1297
[74]
M. Eslani, A. Baradaran-Rafii, A.Y. Cheung, K.H. Kurji, H. Hasani, A.R. Djalilian, et al.
Amniotic Membrane Transplantation in Acute Severe Ocular Chemical Injury: A Randomized Clinical Trial.
Am J Ophthalmol [Internet], (2018),
[75]
A. Tamhane, R.B. Vajpayee, N.R. Biswas, R.M. Pandey, N. Sharma, J.S. Titiyal, et al.
Evaluation of Amniotic Membrane Transplantation as an Adjunct to Medical Therapy as Compared with Medical Therapy Alone in Acute Ocular Burns.
Ophthalmology [Internet], 112 (2005), pp. 1963-1969
[76]
E. Clearfield, B.S. Hawkins, I.C. Kuo.
Conjunctival Autograft Versus Amniotic Membrane Transplantation for Treatment of Pterygium: Findings From a Cochrane Systematic Review.
Am J Ophthalmol [Internet], 182 (2017), pp. 8-17
[77]
M. Li, M. Zhu, Y. Yu, L. Gong, N. Zhao, M.J. Robitaille.
Comparison of conjunctival autograft transplantation and amniotic membrane transplantation for pterygium: a meta-analysis.
Graefe’s Arch Clin Exp Ophthalmol [Internet], 250 (2012), pp. 375-381
[78]
Saeed HN, Chodosh J. Ocular manifestations of Stevens–Johnson syndrome and their management. [cited 2018 Jun 3]; Available from: https://insights.ovid.com/pubmed?pmid=27585215.
[79]
R. Jain, N. Sharma, S. Basu, G. Iyer, M. Ueta, C. Sotozono, et al.
Stevens-Johnson syndrome: The role of an ophthalmologist.
Surv Ophthalmol [Internet], 61 (2016), pp. 369-399
[80]
M. Hsu, A. Jayaram, R. Verner, A. Lin, C. Bouchard.
Indications and Outcomes of Amniotic Membrane Transplantation in the Management of Acute Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis.
Cornea [Internet], 31 (2012), pp. 1394-1402
[81]
D.G. Gregory.
The ophthalmologic Management of Acute Stevens-Johnson Syndrome.
Ocul Surf [Internet], 6 (2008), pp. 87-95
