Abstracts of the 2025 Annual Meeting of the ALEH
More infoDC and ACLF represent critical stages of alcohol-related chronic liver disease. Infections substantially increase mortality; therefore, the search for prognostic markers is important to predict clinical outcomes. Lipid profile has been shown to be associated with immunomodulatory processes and liver dysfunction; however, their role has been little investigated in patients from western Mexico. The objective was to evaluate the lipid profile in patients with alcohol-related DC and ACLF, and its association with infections and mortality.
Materials and MethodsAnalytical cross-sectional study. Serum samples from 91 patients (DC=30, ACLF=61) were analyzed, plus 33 healthy controls (HC). Lipid profile quantification was performed using automated methods. ROC curves and Kaplan-Meier analyses were made using GraphPad. Approval number: 00012. No conflicts of interest are reported.
ResultsACLF group showed a significant decrease in triglycerides, LDL-c, and VLDL-c compared to DC and HC. Importantly, LDL-c and VLDL-c were effective to discriminate DC from ACLF (AUROC=0.73 and 0.71). The significant decrease in HDL-c with infection, and 28- and 90-day mortality in both groups DC and ACLF groups showed an AUROC of 0.72 for infection vs. non-infection, plus 0.98 and 0.75 for 28- and 90-day mortality, respectively. In ACLF, VLDL-c <8 mg/dL was associated with a 25% survival rate at 28 days.
ConclusionsTriglyceride, LDL-c, and VLDL-c levels progressively decline with the severity of cirrhosis. LDL, VLDL, and potentially HDL cholesterol are emerging as practical biomarkers for discriminating infections and mortality in DC and ACLF. These findings demonstrate the impact of lipid profiles on the prognosis and stratification of these patients.
