EVALUATION OF OXIDATIVE STRESS MARKERS IN DISEASES ASSOCIATED WITH ALCOHOL CONSUMPTION.

Introduction and Objectives

Ethanol generates damage in hepatocytes mainly by oxidative stress, resulting in the breakdown products of lipids and proteins, such as Malondialdehyde (MDA), and protein carbonyls (PC). The objective was to determine the behavior of serum markers of oxidative stress in liver diseases associated with alcohol consumption.

Materials and Methods

Observational, retrospective, cross-sectional study that included 300 individuals: 200 from the control group (CT), 50 with alcohol cirrhosis (CiOH) and 50 with alcohol-induced hepatitis (HA). Oxidative stress serum markers, namely MDA and CP, which are products of lipid peroxidation and proteolysis saturation respectively, were measured.

Results

MDA and CP were evaluated. The normal value of these is found in healthy controls, observing a significant increase in the CiOH and HA group. The normal value of MDA is 0.05 nM/mg, finding elevation of

0.11 nM/mg in CiOH and 0.11 nM/mg in HA. Likewise, considering that the normal value of protein carbonyls is 0.07 nM/mg, a difference was observed in CiOH with 0.25 nM/mg and in HA 1.8 nM/mg.

Conclusions

The modification in oxidative stress in CiOH and HA provides guidelines for evaluating the oxidative stress component in alcohol-related disorders to identify medications that prevent oxidation of proteins, lipids, and carbohydrates.

Conflict of interest: None

Protein carbonyls

Malondialdehyde