Abstracts of the 2025 Annual Meeting of the ALEH
More infoConnective Tissue Growth Factor (CTFG) is a multifunctional protein, plays a crucial role as a mediator in fibrogenic pathways involved in the development of liver disease. Objective: To establish the correlation between the cut-off point of serum CTGF values by ELISA and the degree of liver fibrosis determined by transitional elastography in patients with cholestasis diagnosed with primary biliary cholangitis (PBC).
Materials and MethodsProlective, descriptive and analytical study, which included patients with cholestasis, with cirrhosis due to hepatitis C and a control group. Serum CTGF levels were quantified in blood. The degree of fibrosis was determined by transitional elastography. The AUROC was calculated and the cut-off point was obtained with the Youden index to obtain sensitivity and specificity, between CT vs HCV-F4, CT vs CBP-F0, CT vs CBP-F4 and HCV-F4 vs CBP-F4.
Results51 patients with PBC, 15 HCV and 18 controls were included, Age 48±15 years, 75% female.The AUROC for HCV-F4 vs TC was .856 (.718-.994, CI95%) p<.001, cutoff 592.9, S=66.7%, E=94.4% for TC vs PBC-F0 was AUROC=.974 (.929-1.0,CI95%) p<.001, cutoff=596.18, S=93.3%, E=94. 4%, for TC vs PBC-F4 was AUROC=.997 (.989-1.0, CI95%), p<.001, S=100, E=94.4%, for HCV-F4 vs PBC-F0 was AUROC=.857 (.769-.956, CI95%), p<. 001, cutoff=1284.7, S=69.4%, E=93.3% and for HCV-F4 vs PBC-F4 was AUROC= .738 (.557-.918,IC95%), p=.026, cutoff=1288.6, S=53.3%, E= 93.3%.
ConclusionsThere is a direct relationship between serum levels of GFRT of patients with cholestasis and specific cut-off points of discrimination for the different groups.
Conflict of interest: None
