Regístrese
Buscar en
Angiologia e Cirurgia Vascular
Toda la web
Inicio Angiologia e Cirurgia Vascular Aortoesophageal fistula in a patient with carcinoma of the esophagus – Case re...
Journal Information
Vol. 12. Issue 3.
Pages 214-217 (September 2016)
Share
Share
Download PDF
More article options
Visits
2651
Vol. 12. Issue 3.
Pages 214-217 (September 2016)
Case report
DOI: 10.1016/j.ancv.2016.03.003
Open Access
Aortoesophageal fistula in a patient with carcinoma of the esophagus – Case report
Fístula aorto-esofágica em doente com neoplasia do esófago – Caso clínico
Visits
2651
Gonçalo Queiroz de Sousaa,
Corresponding author
queiroz.sousa@gmail.com

Corresponding author.
, Ruy Fernandes e Fernandesa, Luís Mendes Pedroa, Pedro Garridoa, Luís Silvestrea, Paulo Costab, José Fernandes e Fernandesa
a Clínica Universitária de Cirurgia Vascular, Hospital de Santa Maria – Centro Hospitalar Lisboa Norte, Faculdade de Medicina da Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisboa, Portugal
b Clínica Universitária de Cirurgia 1, Hospital de Santa Maria – Centro Hospitalar Lisboa Norte, Faculdade de Medicina da Universidade de Lisboa, Portugal
This item has received
2651
Visits

Under a Creative Commons license
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (5)
Show moreShow less
Abstract

Primary aortoesophgeal fistulas (AEF) are a rare but life-threatening condition because of substantial hemorrhage, requiring fast treatment to ensure patient survival. We report a case of a 69-year-old male with diagnosis of squamous cell carcinoma of the esophagus who suffered an episode of hematemesis and hemorrhagic shock. Gastrointestinal (GI) endoscopy revealed an ulcerated lesion with pulsatile hemorrhage. CT-scan confirmed the diagnosis of AEF. A stent-graft was placed in the descending aorta to control bleeding, and 2 days later an esophageal stent was deployed to reduce risk of aortic graft infection. The patient was discharged 13 days after admission and had no other episode of GI bleeding in a 6-month follow-up period. TEVAR may be used as a palliative or bridge treatment of AEF.

Keywords:
Aortoesophageal fistula
Aorta
Endovascular stentgraft
Esophageal stent
Upper gastrointestinal bleeding
Resumo

As fistulas aorto-esofágicas (FAE) primárias são raras mas com elevada mortalidade devido à hemorragia digestiva substancial, necessitando intervenção rápida para garantir a sobrevivência do doente. Os autores apresentam um caso dum homem de 69 anos com carcinoma esofágico que teve episódio de hematemeses e choque hemorrágico. A endoscopia digestiva alta mostrou lesão ulcerada com hemorragia pulsátil, a angioTC confirmou o diagnóstico de FAE. Foi colocada endoprótese na aorta descendente para controlo da hemorragia; dois dias depois foi colocado stent esofágico para reduzir risco de infecção da endoprótese. O doente teve alta ao décimo terceiro dia, e não foi reportada hemorragia digestiva nos seis meses de seguimento. Este caso mostra como o TEVAR pode ser usado como tratamento paliativo ou temporário duma FAE.

Palavras-chave:
Fístula aorto-esofágica
Aorta
Endoprótese aórtica
Stent esofágico
Hemorragia digestiva alta
Full Text
Introduction

A primary aortoesophageal fistula (AEF) is a communication between the aorta and the esophagus, without previous surgery. Being a rare entity, the most frequent causes are thoracic aortic aneurysm, foreign body ingestion and esophageal malignancy, being the thoracic aortic aneurysm by far the most common cause.1 It is a life-threatening condition due to massive upper gastrointestinal bleeding, so prompt treatment is mandatory for patient survival.

Here we report a case of primary AEF treated successfully with a stent-graft.

Clinical case

A 63-year-old caucasian male, with coronary heart disease (NSTEMI in 2007) and known diagnosis of squamous cell carcinoma of the esophagus since early 2014, which had been staged T3N+M0 in June 2014, underwent neoadjuvant chemotherapy (two cycles of cisplatin+5-fluorouracil) and radiotherapy (50.4Gy) between July and September and had surgery of the esophagus scheduled for mid-October.

However, in early October he was admitted to the Emergency Department with fever (39.2°C) plus vomits and melena for 3 days. He presented with hypotension (96/59mmHg), and had a painless abdomen on observation. Lab results revealed a hemoglobin of 10.5g/dL, platelets of 31,200/μL and reactive C protein of 15.2mg/dL.

He was transferred to a Medicine Ward and on the next day suddenly lost conscience after an episode of hematemesis. His hemoglobin fell to 6.8g/dL. After fluid resuscitation, the patient recovered from the hemorrhagic shock. An upper gastrointestinal endoscopy showed an ulcerated middle esophagial neoplastic lesion, with a high output, pulsatile hemorragy, with high probability of AEF (Fig. 1). A CT angiogram was performed, and identified the presence of air bubbles between the aorta and the esophagus, with irregularity of the aortic contour in this location, with extravasion of contrast in the arterial phase of the exam, suggestive of AEF (Figs. 2 and 3).

Figure 1.

Ulcerated middle esophageal neoplastic lesion, with high output, pulsatile hemorragy.

(0.08MB).
Figure 2.

Irregularity of the aortic contour with relation to esophageal wall neoplastic formation.

(0.14MB).
Figure 3.

Presence of extra-luminal air bubbles between the aorta and the esophagus.

(0.11MB).

After admission in the ICU, and following a multidisciplinary discussion of the case, endovascular treatment was performed with a Cook® Zenith TX2 30mm×140mm stent graft deployed in the descending aorta, beyond the origin of the left subclavian artery (Fig. 4). Two days later a covered self-expandable esophageal stent was placed with the intent of reducing the risk of aortic stent graft infection (Fig. 5). Both procedures had no short-term complications. The patient had no more episodes of gastrointestinal bleeding, kept hemodynamic stability, and was discharged 13 days after admission in the Hospital Emergency Department.

Figure 4.

Aortic and esophageal stentgrafts.

(0.08MB).
Figure 5.

Covered self-expandable esophageal stent.

(0.1MB).

Since then, the patient kept follow-up in outpatient clinic, is doing prophylactic therapy with amoxicillin clavulanate, and has had several re-admissions in Medicine Ward with difficult-to-control pain, dysphagia for solid food but not for liquids, and progressive weight loss. There were no more episodes of gastrointestinal bleeding reported in a 6-month follow-up period.

Discussion

This case reports a life-threatening condition that requires fast decisions in order to save a patient's life, while trying to offer a lasting solution for the esophageal and the aortic lesions.

In 1991, Hollander and Quick published a review of the available literature regarding AEF, where esophageal cancer was the third leading cause of AEF, and at that time rapid surgical intervention was recommended as the only chance for patient survival, since all the cases which had been managed in a conservative way had died of exsanguination.1

After the introduction of endovascular aortic repair,2 a new alternative for the treatment of AEF has been proposed.

In these patients there is another challenge, infection. One must consider that infection is, by principle, present in this group of patients3,4 which makes open surgery and debridement of infected tissues the treatment of choice for these patients. The commonly used technique for open repair of AEF requires left thoracotomy and aortic replacement or even extra-anatomic bypass in cases of serious infection.5 However, open surgery is related with high-mortality rate in this group of patients,1 although exact mortality rates are not available in literature due to the low number of cases of AEF.

This is why endovascular exclusion of thoracic aortic fistulas with TEVAR may definitely have a role, especially in the rapid control of hemorrhage in often physically and physiologically fragile patients.6

In the literature there are only small series or case reports published describing the use of TEVAR in the management of AEF, but this technique should be considered as a palliative treatment,7 or a “bridge” until the patient is healthy enough to endure open surgery,3,7 with broad-spectrum antibiotherapy to control infection. Allen4 considers that TEVAR “should be used only for specific indications, such as infection with low-virulence organisms, absence of gross purulence, and high operative risk”.

Moreover, after the diagnosis of the AEF this tumor is now a T4b (unresectable), and staged IIIc, which according to the NCCN guidelines is candidate for chemotherapy if the patient tolerates it, or only palliative management.9

In our patient, and in order to reduce the contact of the endograft with the septic environment of the esophagus as well as providing sealing of the fistula on the esophageal side, a self-expandable covered esophageal stent was used. One report8 describes the use of an esophageal stent as the first means to tamponade and control hemorrhage from AEF, followed by TEVAR. In this report, the patient died 2 months later of disseminated malignancy.

Conclusion

Endovascular management of urgent cases of AEF with TEVAR is a feasible technique, and may have a role in a specific group of patients, especially those that do not have conditions for open surgery or are in terminal phase of malignant disease.

The use of concomitant esophageal stenting may have the potential of reducing the infection of the aortic stent-graft, but this needs to be supported by other studies.

However, there is only a low number of published cases, and we have limited time of follow-up, so more evidence is necessary to evaluate long-term outcomes of this treatment option for AEF.

Ethical diclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this investigation.

Confidentiality of data

The authors declare that no patient data appears in this article.

Right to privacy and informed consent

The authors declare that no patient data appears in this article.

Conflicts of interest

The authors have no conflicts of interest to declare.

References
[1]
J.E. Hollander, G. Quick.
Aortoesophageal fistula: a comprehensive review of the literature.
Am J Med, 91 (1991), pp. 279-287
[2]
J.C. Parodi, F.J. Criado, H.D. Barone, et al.
Endoluminal aortic aneurysm repair using a balloon-expandable stent-graft device: a progress report.
Ann Vasc Surg, 8 (1994), pp. 523-529
[3]
J.A. González-Fajardo, V. Gutierréz, M. Martin-Pedrosa, et al.
Endovascular repair in the presence of aortic infection.
Ann Vasc Surg, 19 (2005), pp. 94-98
[4]
R.C. Allen, M.G. Sebastian.
The role of endovascular techniques in aortoesophageal fistula repair.
[5]
I. Topel, A. Stehr, M.G. Steinbauer, et al.
Surgical strategy in aortoesophageal fistulae: endovascular stentgrafts and in situ repair of the aorta with cryopreserved homografts.
Ann Surg, 246 (2007), pp. 853-859
[6]
F.H.W. Jonker, R. Heijmen, S. Trimarchi, et al.
Acute management of aortobronchial and aortoesophageal fistulas using thoracic endovascular aortic repair.
J Vasc Surg, 50 (2009), pp. 999-1004
[7]
J. Flores, N. Shiya, T. Kunihara, et al.
Aortoesophageal fistula: alternatives of treatment case report and literature review.
Ann Thorac Cardiovasc Surg, 10 (2004), pp. 241-246
[8]
S.K. Ghosh, F.Z. Rahman, S. Bown, et al.
Survival following treatment of aortoesophageal fistula with dual esophageal and aortic intervention.
Case Rep Gastroenterol, 5 (2011), pp. 40-44
[9]
J.A. Ajani, J.S. Barthel, D.J. Bentrem, et al.
Esophageal and esophagogastric junction cancers.
J Natl Compr Canc Netw, 9 (2011), pp. 830-887
Copyright © 2016. Sociedade Portuguesa de Angiologia e Cirurgia Vascular
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.