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Allergologia et Immunopathologia
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Journal Information
Vol. 44. Issue 5.
Pages 410-414 (September - October 2016)
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Vol. 44. Issue 5.
Pages 410-414 (September - October 2016)
Original Article
DOI: 10.1016/j.aller.2015.07.004
Recurrent wheezing and asthma after bocavirus bronchiolitis
T. del Rosala, M.L. García-Garcíab,
Corresponding author

Corresponding author.
, C. Calvob, F. Gozalob, F. Pozoc, I. Casasc
a Pediatrics Department, Hospital Universitario La Paz, Madrid, Spain
b Pediatrics Department, Hospital Severo Ochoa, Madrid, Spain
c Influenza and Respiratory Viruses Laboratory, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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Tables (3)
Table 1. Evaluation of background factors in children with RSV and HBoV bronchiolitis.
Table 2. Respiratory evolution after HBoV and RSV bronchiolitis.
Table 3. Univariate test of various possible risk factors for asthma and current asthma.
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Human bocavirus (HBoV) was recently discovered and identified as an important cause of respiratory infection in young children. However, the relationship between HBoV-bronchiolitis and the development of recurrent wheezing has not yet been established.


We designed this study in order to describe the mid-term outcome, regarding the development of recurrent wheezing and asthma of HBoV-bronchiolitis patients and to compare it with RSV-bronchiolitis infants.


We studied 80 children (10 with HBoV and 70 with RSV infection), currently aged ≥4 years and previously hospitalised during the seasons 2004–2009 due to acute bronchiolitis. Epidemiological and clinical data were collected through structured clinical interviews at the follow-up visit. Spirometry and skin prick tests to common food and inhaled allergens were performed.


All HBoV-patients developed recurrent wheezing and half of them had asthma at age 5–7 years. Almost 30% required hospital admission for recurrent wheezing. Asthma (odds ratio (OR)=1.28) and current asthma (OR=2.18) were significantly more frequent in children with HBoV-bronchiolitis than in RSV-bronchiolitis. FEV1 values were 99.2±4.8 in HBoV-group vs. 103±11 in RSV-group, p: 0.09. No differences were found with respect to allergic rhinitis, atopic dermatitis, food allergy, proportion of positive prick tests, and family history of atopy or asthma.


Severe HBoV-bronchiolitis in infancy was strongly associated with asthma at 5–7 years.

Human bocavirus
Recurrent wheezing


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