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Inicio Allergologia et Immunopathologia Preconceptional allergen immunization can induce offspring IL-17 secreting B cel...
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Vol. 46. Issue 5.
Pages 454-459 (September - October 2018)
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Vol. 46. Issue 5.
Pages 454-459 (September - October 2018)
Original Article
DOI: 10.1016/j.aller.2018.04.001
Preconceptional allergen immunization can induce offspring IL-17 secreting B cells (B17): do they share similarities with regulatory B10 cells?
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Aline Aparecida de Lima Liraa, Marília Garcia de-Oliveiraa, Amanda Harumi Sabô Inouea, Giovanna Rossi Beltramea, Alberto José da Silva Duartea,b, Jefferson Russo Victora,b,c,
Corresponding author
victorjr@usp.br

Corresponding author.
a Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil
b Division of Pathology, Medical School, University of Sao Paulo, Sao Paulo, Brazil
c Division of Environmental Health, FMU, Laureate International Universities, Sao Paulo, Brazil
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Abstract
Background

IL-17-producing B cells can be identified in both mice and human and were named B17 cells. The role of B17 cells still needs to be elucidated and its inflammatory or regulatory functions remain controversial.

Objective

We evaluate the effect of maternal immunization with OVA on offspring B cells that produces IL-17 and can show a regulatory potential by IL-10 production.

Methods

C57BL/6 WT, IL-10−/− or CD28−/− female mice were immunized or not with OVA in Alum, and immunized females were boosted after 10 and 20 days. Immunized and non-immunized females were mated, and pups from both groups were evaluated at 3 or 20 days old (d.o.). Some offspring from the aforementioned two groups were immunized with OVA at 3 d.o., boosted after 10 days and evaluated at 20 d.o.

Results

Maternal immunization with OVA induced offspring B cells to produce IL-17 at higher intensity compared to the control group of offspring at 3 d.o. This effect was maintained until 20 d.o. and even after neonatal immunization with OVA. The co-production of IL-10 on offspring IL-17+B cells is up-regulated in response to maternal immunization with OVA. Maternal immunization with OVA on IL-10−/− mice reveals reduced percentage and mean of fluorescence intensity of IL-17 on B cells of offspring.

Conclusion

Preconception OVA immunization can induce offspring B cells that produce IL-17 at higher intensity and co-produce mainly IL-10. This could be the reason why B17 cells had been described in the literature with controversial roles upon their regulatory function.

Keywords:
Allergy
OVA
Maternal–fetal interface
IL-17
B cells

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