Buscar en
Actas Urológicas Españolas (English Edition)
Toda la web
Inicio Actas Urológicas Españolas (English Edition) Usefulness and predictive value of PSA density, adjusted by transition zone volu...
Journal Information
Vol. 36. Issue 2.
Pages 93-98 (February 2012)
Share
Share
Download PDF
More article options
Visits
1389
Vol. 36. Issue 2.
Pages 93-98 (February 2012)
Original article
Usefulness and predictive value of PSA density, adjusted by transition zone volume, in men with PSA levels between 2 and 4ng/ml
Utilidad y valor predictivo de la densidad de PSA ajustada por el volumen de la zona de transición en hombres con niveles de PSA entre 2 y 4 ng/ml
Visits
1389
A. Jananea,
Corresponding author
a.janane@yahoo.fr

Corresponding author.
, F. Hajjia, T. Ismaila, C. Jawada, J.C. Elondoa, Y. Dakkaa, M. Ghadouanea, A. Ameura, M. Abbara, A. Albouzidib,c
a Department of Urology, Universitary Military Hospital Med V, Rabat, Morocco
b Department of Pathology, Universitary Military Hospital Med V, Rabat, Morocco
c Faculty of Medicine, University Mohamed V, Rabat, Morocco
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (2)
Table 1. Clinical findings in all participants and clinicopathological features in patients with prostate cancer.
Table 2. Sensitivity, specificity, and efficiency on the cut-off points of PSA parameters related to the prostate volume.
Show moreShow less
Abstract
Objective

To assess the diagnostic significance of prostate-specific antigen (PSA), density (PSAD) accuracy, and PSAD adjusted by transition zone volume (PSATZD) in men with PSA levels between 2.0 and 4.0ng/ml.

Methods

Between 2000 and 2010, 138 men with PSA levels between 2 and 4.0ng/ml underwent transrectal ultrasonography (TRUS) and 12-core prostate biopsy. Diagnostic accuracies for various cut-offs of PSAD and PSATZD were investigated according to subdivided PSA levels of 2.0–3.0ng/ml and 3.1–4.0ng/ml.

Results

The detection rate of prostate cancer was 23, 8% (32/134). The percentage of patients with extracapsular disease was 28.1% (10/32) and primary Gleason grade 4 or 5 was obtained in 8/32 cases (25%) patients. The transition zone volume and PSATZD in cancer cases were significantly different in comparison with those in non-cancer cases. The area under the receiver operating characteristic curve for PSATZD was significantly higher in comparison with that for PSAD in the same subdivided PSA ranges. The diagnostic efficiency for PSATZD was higher than that for PSAD. The diagnostic efficiency showed the highest value at the cut-off level for PSATZD of 0.23 and 0.28 in men with PSA levels of 2.0–3.0ng/ml and 3.1–4.0ng/ml, respectively.

Conclusions

The use of PSATZD cut-offs as a biopsy indication may reduce many unnecessary biopsies without missing most prostate cancer cases in the PSA range of 2.0–4.0ng/ml.

Keywords:
Prostate cancer
Prostate-specific antigen
Prostate volume
PSA transition zone density
Resumen
Objetivo

Evaluar la significancia diagnóstica del PSA, de su densidad (PSAD) y de la PSAD ajustada por el volumen de la zona de transición (PSATZD) en hombres con niveles de PSA entre 2,0 y 4,0 ng/ml.

Métodos

Entre el 2000 y el 2010, 138 hombres con niveles de PSA entre 2,0 y 4,0 ng/ml fueron sometidos a ultrasonografía transrectal (TRUS) y biopsia prostática de 12 fragmentos. Se investigó la precisión diagnóstica de varios puntos de corte de la PSAD y de la PSATZD en rangos de PSA de 2,0 a 3,0 ng/ml y de 3,1 a 4,0 ng/ml.

Resultados

La tasa de detección del cáncer de próstata fue de 23,9% (32/134). El porcentaje de pacientes con enfermedad extracapsular fue de 28,1% (10/32) y se obtuvo primarios de grado Gleason 4 o 5 en 8 de 32 casos (25%). El volumen de la zona de transición y la PSATZD en los casos de cáncer fueron significativamente diferentes en comparación con los obtenidos en los casos sin cáncer. El área bajo la curva de la característica operativa del receptor (ROC) de la PSATZD fue significativamente mayor que la de la PSAD en los mismos rangos de subdivisión del PSA. La eficiencia diagnóstica de la PSATZD fue mayor que la de la PSAD. La eficiencia diagnóstica fue mayor en los niveles de corte de PSATZD de 0,23 y 0,28 en hombres con valores de PSA de 2,0 a 3,0 ng/ml y de 3,1 a 4,0 ng/ml respectivamente.

Conclusiones

El uso de puntos de corte de la PSATZD como indicación para biopsias evitaría muchas biopsias innecesarias sin pasar por alto la mayor parte de cánceres de próstata en el rango de PSA de 2,0 a 4,0 ng/ml.

Palabras clave:
cáncer de próstata
antígeno prostático específico
volumen prostático
densidad de PSA en zona de transición

Article

These are the options to access the full texts of the publication Actas Urológicas Españolas (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Actas Urológicas Españolas (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos