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Vol. 35. Issue 9.
Pages 515-522 (October 2011)
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Vol. 35. Issue 9.
Pages 515-522 (October 2011)
Original article
DOI: 10.1016/j.acuroe.2011.04.006
Relationships between sex hormone levels in men over 50 years of age and body composition, bone quality, and quality of life
Relación entre los niveles de hormonas sexuales en varones por encima de los 50 años y composición corporal, calidad ósea y calidad de vida
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J.M. Martínez-Jabaloyasa,??
Corresponding author
jaba@pulso.com

Corresponding author.
, A. Queipo-Zaragozáb, C. Ferrandis-Cortesa, J.A. Queipo-Zaragozác, M. Gil-Saloma, P. Chuan-Nueza
a Servicio de Urología, Hospital Clínico Universitario de Valencia, Valencia, Spain
b Laboratorio de Bioquímica Clínica, Hospital Clínico Universitario de Valencia, Valencia, Spain
c Servicio Urología, Hospital Clínico de Sagunto, Valencia, Spain
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Tables (7)
Table 1. Clinical characteristics.
Table 2. Relation between body composition parameters and clinical characteristics, and sex hormone levels for quantitative variables. Results of Spearman and Pearson's tests. Only the statistically significant results (p<0.05) are shown.
Table 3. Relation between body composition parameters and clinical characteristics, and hormone levels for qualitative variables. Mann–Whitney U test's results. Only the statistically significant results (p<0.05) are shown.
Table 4. Relation between body composition parameters and clinical characteristics, and hormone levels. Statistically significant results (p<0.05) in multivariate analysis (multiple linear regression).
Table 5. Relation between 36-SF subscales and clinical characteristics, and hormone levels for quantitative variables. Results of Spearman or Pearson's test. Only the statistically significant variables (p<0.05) are shown.
Table 6. Relation between 36-SF subscales and clinical characteristics, and hormone levels for quantitative variables. Results of the Mann–Whitney's U test. Only the statistically significant variables (p<0.05) are shown.
Table 7. Relation between the SF-36 subscales and the subscales of quality of life of the HRQol. Statistically significant variables (p<0.05) in the multivariate analysis (multiple linear regression).
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Abstract
Objetive

To determine whether there was a relationship between sex hormone levels and body composition, bone health, and health-related quality of life in men over 50 years of age.

Material and methods

Transversal study carried out in 230 Spanish male outpatients. Body composition was studied using direct anthropometric measures: height, weight, waistline circumference, dominant arm circumference, tricipital skinfold, dominant arm skinfold, subscapular skinfold. Calculated anthropometric parameters were obtained. Quantitative ultrasound measurements of the calcaneus were performed and bone turnover markers were determined (N-telopeptides urinary excretion and calcium/creatinine urinary rate). Quality of life was studied using the short form 36 questionnaire (SF-36). Blood tests included total testosterone, sex hormone-binding globulin, calculated free testosterone (cFT), dehydroepiandrosterone sulfate (DHEA-S), androstenedione, 17-β-estradiol and gonadotrophins.

Results

cFT was associated with increased muscle and to decreased in fat content, even after adjusting for age (p<0.05). Bone density was only related to estradiol and its bioavailable fraction (p<0.05). DHEA-S and cFT were related (p<0.05) to some SF-36 subscales.

Conclusions

cFT level is most associated with body changes that accompany aging. Androgen levels are not related to bone density. Decline in cFT and DHEA-s levels might be related to decreased quality of life.

Keywords:
Androgens
Testosterone
Aging male
Anthropometry
Quality of life
Bone density
Resumen
Objetivo

Determinar la relación existente entre los niveles de hormonas sexuales y la composición corporal, la salud ósea y la calidad de vida en hombres por encima de los 50 años.

Material y métodos

Estudio transversal en el que se incluyen 230 pacientes. Se determina la composición corporal utilizando parámetros antropométricos directos como el peso, la talla, la circunferencia de la cintura, la circunferencia del brazo dominante, el pliegue cutáneo tricipital, el pliegue en brazo dominante y el pliegue subcapsular. Se calculan parámetros antropométricos indirectos. Se realizan medidas cuantitativas de densidad ósea mediante ecografía del calcáneo, así como marcadores de recambio óseo (N-telopéptidos de excreción urinaria y relación calcio/ creatina). La calidad de vida se evalúa mediante el cuestionario abreviado de calidad de vida SF-36. Los análisis sanguíneos incluyen la determinación de testosterona total, globulina transportadora de hormonas sexuales (SHBG), testosterona libre calculada (TLc), sulfato de dehidroepiandrosterona (S-DHEA), androsteriona, 17-β-estradiol y gonadotropinas.

Resultados

La TLc se asocia con un incremento muscular y una disminución del contenido graso, aun ajustándolo por edad (p<0,05). La densidad ósea sólo se relaciona con los niveles de estradiol y su fracción biodisponible (p<0,05). El S-DHEA y la TLc están asociadas a algunas subescalas del SF-36 (p<0,05).

Conclusiones

La TLc es la hormona que mejor se relaciona con los cambios corporales asociados a la edad; sin embargo, los niveles de andrógenos no están asociados a la densidad ósea. Un descenso en la TLc y el S-DHEA podría estar relacionado con un descenso en la calidad de vida.

Palabras clave:
Andrógenos
Testosterona
Varón añoso
Antropometría
Calidad de vida
Densidad ósea

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