Buscar en
Actas Urológicas Españolas (English Edition)
Toda la web
Inicio Actas Urológicas Españolas (English Edition) Multivariate analysis of predictive factors in the evolution of renal lithiasis
Journal Information
Vol. 36. Issue 6.
Pages 346-351 (June 2012)
Share
Share
Download PDF
More article options
ePub
Visits
980
Vol. 36. Issue 6.
Pages 346-351 (June 2012)
Original article
Multivariate analysis of predictive factors in the evolution of renal lithiasis
Análisis multivariante de factores predictivos de evolución en litiasis renal
Visits
...
E. Pierasa,??
Corresponding author
32477apa@comb.es

Corresponding author.
, J. Ruizb, A. Vicensa, G. Fronteraa, F. Grasesc, P. Pizáa
a Servicio de Urología, Hospital Universitario Son Espases, Palma de Mallorca, Spain
b Servicio de Urología, Hospital Universitario Joan XXIII, Tarragona, Spain
c Laboratorio de Investigación en Litiasis Renal, Universidad Islas Baleares, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (3)
Table 1. Lithogenic risk values in serum and urine.
Table 2. Summary of variables analyzed and results of univariate analysis.
Table 3. Multivariate analysis of the variables which were significant in the univariate analysis.
Show moreShow less
Abstract
Objective

To perform a multivariate statistical analysis of epidemiological, clinical and biochemical factors that make it possible to identify the variables that can independently predict the course of renal lithiasis, thus defining a group at risk of worse evolution.

Materials and methods

A retrospective, descriptive and analytic study was in a cohort of 248 patients with kidney stones treated in our center from 2003 to 2007. A univariate analysis (Chi-square) and a multivariate analysis (regression model) of possible epidemiological predictive factors (age and gender), clinical data of stones (number, localization, size and bilaterality) and biochemical factors (urinary composition and stone composition) were analyzed.

Results

Based on a mean follow-up of 60 months (95% CI: 52.5–67.4) we observed a global persistence of kidney stones in 121 patients (48.8%) and 127 patients being stone-free (51.2%). The univariate analysis describes the following variables as being associated to greater persistence of lithiasis: age, number of stones, calyceal localization and bilaterality, urinary biochemical composition, and stone biochemical composition. In regards to all of the above variables, only age less than 47 years, bilaterality, stone localization and chemical composition of the lithiasis (oxalate calcium dehydrated) were significantly associated to a major risk of persistence of kidney stones.

Conclusion

There is a high persistence rate of kidney stones. Patient age inferior to 47 year, calyceal localization, bilaterality, and biochemical composition of stones (oxalate calcium dihydrate) are independent factors associated to higher persistence rate of kidney stones. These factors indicate a risk group with a worse clinical prognosis in which we should reconsider more individualized diagnostic and therapeutic strategies.

Keywords:
Kidney stone
Multivariate analysis
Risk factor
Predictive factor
Natural history
Resumen
Objetivo

Realizar un análisis estadístico multivariante de factores epidemiológicos, clínicos y bioquímicos que permitan identificar las variables que independientemente puedan predecir la evolución de la litiasis renal, definiendo así un grupo de riesgo con peor evolución.

Material y métodos

Estudio analítico, descriptivo, retrospectivo sobre 248 pacientes visitados en nuestro centro en el periodo 2003-2007. Se ha realizado análisis univariante (Chi-cuadrado) y multivariante (regresión logística) de posibles factores predictivos epidemiológicos (sexo, edad), clínicos (antecedentes personales de litiasis, número, localización caliciar y tamaño de cálculos, bilateralidad) y bioquímicos (bioquímica urinaria y composición del cálculo) en relación con la evolución de la litiasis renal (limpio o persistencia renal).

Resultados

Con un seguimiento medio de 60 meses (IC 95%=52,5-67,4) observamos una persistencia global de litiasis renal en 121 pacientes (48,8%), estando limpios de litiasis 127 pacientes (51,2%). El análisis univariante describe como variables asociadas a mayor persistencia de litiasis la edad, el número de litiasis, la localización calicilar, la bilateralidad, la composición bioquímica urinaria y la composición bioquímica del cálculo; de todas estas variables, en el análisis multivariante solo mantienen significación estadística la edad inferior a 47 años, la bilateralidad, la localización calicilar y la composición química de la litiasis (oxalato cálcico dihidrado).

Conclusiones

Existe una elevada persistencia de litiasis renal. La edad inferior a 47 años, la bilateralidad, la localización calicilar y la composición química de la litiasis (oxalato cálcico dihidrato) son factores asociados a mayor persistencia de litiasis renal de forma independiente. Estos factores señalan un grupo con peor evolución clínica, en los que deberíamos replantear estrategias diagnósticas y terapéuticas más individualizadas.

Palabras clave:
Litiasis renal
Análisis multivariante
Factor riesgo
Factores predictivos
Evolución

Article

These are the options to access the full texts of the publication Actas Urológicas Españolas (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Actas Urológicas Españolas (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos