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Vol. 42. Issue 4.
Pages 262-266 (May 2018)
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Vol. 42. Issue 4.
Pages 262-266 (May 2018)
Original article
Apoptotic effect as biomarker of disease, severity and follow-up in interstitial cystitis
Efecto apoptótico como biomarcador de enfermedad, severidad y seguimiento en la cistitis intersticial
C. Di Capua-Sacotoa, A. Sanchez-Llopisb,
Corresponding author

Corresponding author.
, J.E. Oconnorc, A. Martinez-Romerod, J.L. Ruiz-Cerdáe
a Departamento de Urología, Hospital La Plana de Villarreal, Castellón, Spain
b Departamento de Urología, Hospital Universitario General de Castellón, Castellón, Spain
c Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Valencia, Spain
d Servicio Tecnológico de Citómica, Centro de Investigación Príncipe Felipe, Valencia, Spain
e Departamento de Urología, Hospital Universitario La Fe, Valencia, Spain
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Figures (2)
Tables (2)
Table 1. Degree of symptomatic severity of patients with interstitial cystitis.
Table 2. Degree of apoptotic effect due to symptomatic severity (GUPI) in the group of patients with IC.
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To determine whether the apoptotic effect test could serve as a biomarker of severity in bladder pain syndrome/interstitial cystitis.

Material and methods

A prospective study was conducted between January 2010 and January 2015, which included 57 patients diagnosed with interstitial cystitis and 49 diagnosed with chronic pelvic pain of gynecological origin. The urine was exposed to cell cultures, and the urine's capacity for inducing apoptosis in the cultures was analyzed. A statistical analysis was then conducted to assess whether the apoptotic effect was associated with the symptoms.


After performing an analysis of the association between the degree of apoptotic effect and the symptoms of patients with interstitial cystitis, we observed a significant increase in the mean percentages of apoptosis as the degree of symptom severity increased. After analyzing the association between the apoptotic effect and symptoms, we obtained a positive correlation in the patients with interstitial cystitis and a lack of correlation in the patients with chronic pelvic pain of gynecological origin. The rates of apoptosis increased progressively in the patients with interstitial cystitis as the symptoms increased, while the patients with chronic pelvic pain of gynecological origin remained stable.


The apoptotic effect of the urine of patients with interstitial cystitis could be a marker of disease, thus differentiating patients with interstitial cystitis from patients with chronic pelvic pain. The effect could also provide an objective measure of symptom severity.

Interstitial cystitis

Estudiar si el test de efecto apoptótico podría servir como biomarcador de severidad en el síndrome de dolor vesical/cistitis intersticial.

Material y métodos

Se realizó un estudio prospectivo entre enero de 2010 y enero de 2015, se incluyeron 57 pacientes diagnosticadas de cistitis intersticial y 49 de dolor pélvico crónico de origen ginecológico. Se expuso la orina a cultivos celulares y se analizó su capacidad para inducir apoptosis en ellos. Posteriormente se llevó acabó un análisis estadístico para valorar si el efecto apoptótico se asociaba con la sintomatología.


Al realizar un análisis de la asociación entre el grado del efecto apoptótico y la sintomatología de las pacientes con cistitis intersticial, se observó un aumento significativo de los porcentajes medios de apoptosis a medida que aumenta el grado de severidad sintomatológica. Al analizar la asociación entre el efecto apoptótico y la sintomatología, se obtuvo una correlación positiva en los pacientes con cistitis intersticial y una ausencia de correlación en los pacientes con dolor pélvico crónico de origen ginecológico. Los porcentajes de apoptosis aumentan de manera progresiva en las pacientes con cistitis intersticial a medida que presentan mayor sintomatología mientras que los pacientes con dolor pélvico crónico de origen ginecológico permanecen estables.


El efecto apoptótico de la orina de pacientes con cistitis intersticial podría ser un marcador de enfermedad, permitiendo diferenciar las pacientes afectas de cistitis intersticial de pacientes con dolor pélvico crónico y además poder tener una medida objetiva del grado de severidad de los síntomas.

Palabras clave:
Cistitis intersticial


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