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Inicio Acta Otorrinolaringológica Española Two Cases of Spontaneous Angina Bullosa Hemorrhagica
Journal Information
Vol. 67. Issue 5.
Pages 300 (September - October 2016)
Vol. 67. Issue 5.
Pages 300 (September - October 2016)
Images in Otorhinolaryngology
DOI: 10.1016/j.otoeng.2015.09.005
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Two Cases of Spontaneous Angina Bullosa Hemorrhagica
Dos casos de angina bullosa hemorrágica espontánea
Belén Lozano-Masdemont
Corresponding author

Corresponding author.
, Marta Bergón-Sendín, Ricardo Suárez-Fernández
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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The first case is that of a female aged 51 who presented with a haemorrhagic blister of approximately 30mm on the side of her tongue which had appeared annually for 15 years (Fig. 1). She did not wear dentures or braces and stated she had received no episodes of trauma. The second case is that of a female aged 40 who had had 3 outbreaks of haemorrhagic blisters during the last few months. A single 3mm blister was detected in the buccal mucosa and, similarly to the previous patient, she denied precipitating factors (Fig. 2). Angina bullosa hemorrhagica is a condition of unknown origin which consists of the presence of blisters of haemorrhagic content in the oral cavity, mainly in the soft palate which may compromise the airway. They have been related with trauma, the ingestion of hot or spicy foods, inhaled corticosteroids and high blood pressure. None of these possible causes were identified in our patients. In the longest study to date, with 16 patients, 75% of cases could have been associated with the ingestion of hot or spicy foods and none of them were recurrent, which differs from the 2 cases presented here. Histology shows a sub epithelial blister of haemorrhagic content with low inflammatory component, or abundant neutrophilic component. They cure spontaneously with no scar. It is important to study coagulation and the platelets for ruling out underlying blood dyscrasias. The ruling out of other diseases such as blistering gallbladder diseases (biopsy, direct and indirect immunofluorescence) with its resulting cost is more controversial, when lesions are single, self-resolving and localised.


Please cite this article as: Lozano-Masdemont B, Bergón-Sendín M, Suárez-Fernández R. Dos casos de angina bullosa hemorrágica espontánea. Acta Otorrinolaringol Esp. 2016;67:300.

Copyright © 2015. Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello
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