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Vol. 62. Issue 2.
Pages 95-102 (January 2011)
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Vol. 62. Issue 2.
Pages 95-102 (January 2011)
Original Article
Transoral laser microsurgery in advanced carcinomas of larynx and pharynx
Cirugía transoral LASER CO2 en tumores avanzados de faringe y laringe
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Fernando López-Álvareza,b,
Corresponding author
flopez1981@yahoo.es

Corresponding author.
, Juan P. Rodrigoa,b, José L. Llorente-Pendása,b, Carlos Suárez-Nietoa,b
a Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias, Oviedo, Spain
b Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
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Abstract
Introduction and objectives

There are several types of treatment for advanced squamous cell carcinomas of the pharynx and larynx. However, both open surgery and chemoradiation protocols have failed to improve control and survival. There is a tendency toward conservative treatment without worsening oncological outcomes. The objective of this study was to describe the effectiveness of organ-preserving CO2 laser microsurgery for treating advanced carcinomas of the larynx and pharynx.

Material and method

A retrospective review of 63 patients undergoing CO2 laser microsurgery for the treatment of squamous cell carcinomas of the pharynx and larynx in advanced stages (stages III and IV) was performed. Tumour distribution was 14 patients with a tumour at the base of the tongue, 16 with a pyriform sinus tumour, 29 with a supraglottic tumour and 4 with a glottic tumour. Mean follow-up was 51 months.

Results

Thirty-five percent of patients (23) had recurrences. The recurrence rate was 28% for base of tongue tumours, 50% for hypopharyngeal tumours, 27% for supraglottic tumours and 75% for glottic tumours. The 5-year disease-specific survival rate was 73.3% for all locations, with a range from 90% for supraglottic tumours up to 50% for glottic tumours. Thirty-four percent of patients had some type of complication after surgery. The most frequent complication was local bleeding (17%).

Conclusion

Transoral CO2 laser microsurgery is an alternative for the treatment of carcinomas of the pharynx and larynx in advanced stages. Its oncological results are equivalent to other treatment modalities and its morbidity is lower.

Keywords:
Advanced tumours of the pharynx and larynx
Laser
Treatment
Resumen
Introducción y objetivos

Existen diversas modalidades terapéuticas de los carcinomas epidermoides avanzados de faringe y laringe. Se han propuesto nuevas estrategias que, sin empeorar los resultados oncológicos, disminuyan la morbilidad generada por los tratamientos agresivos. Entre estos tratamientos se encuentra la microcirugía transoral LASER CO2 (MTL). El objetivo de este estudio es describir los resultados de los pacientes con carcinomas avanzados de laringe y faringe tratados mediante este método en nuestro departamento.

Material y método

Realizamos un estudio retrospectivo en 63 pacientes con tumores de faringe y laringe en estadios avanzados (estadios III y IV) intervenidos mediante MTL entre los años 2000 y 2008. Catorce pacientes tenían un tumor de base de lengua, 16 un tumor de seno piriforme, 29 un tumor supraglótico y 4 un tumor glótico. El tiempo medio de seguimiento fue de 51 meses.

Resultados

El 28% de tumores de base de lengua, el 50% de tumores de hipofaringe, el 27% de tumores de supraglotis y el 75% de los tumores glóticos recidivaron. La supervivencia específica fue del 73,3% para todas las localizaciones con un rango que va desde el 90% para los tumores de supraglotis hasta el 50% para los tumores glóticos. El 34% de los pacientes presentaron algún tipo de complicación tras la cirugía, siendo la hemorragia local la más frecuente (17%).

Conclusiones

La MTL es una alternativa válida para el tratamiento de los carcinomas de faringe y laringe en estadios avanzados. Sus resultados oncológicos son similares a los obtenidos en otras modalidades terapéuticas y la morbilidad generada es menor.

Palabras clave:
Tumores avanzados de faringe y laringe
LASER
Tratamiento

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