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Vol. 72. Issue 5.
Pages 280-287 (September - October 2021)
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Vol. 72. Issue 5.
Pages 280-287 (September - October 2021)
Original article
Topical versus interlesional mitomycin C in auricular keloids
Mitomicina C tópica vs interlesional en queloides auriculares
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Yasser Mandour
Corresponding author
ghader_massoud@yahoo.com

Corresponding author.
, Hossam Bake, Esmael Mofty, Eman Ramadan, Mostafa Gomaa, Essam Akl, Ahmed Elrefae
Faculty of Medicine, Benha University, Benha, Egypt
Article information
Abstract
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Figures (5)
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Tables (5)
Table 1. Vancouver scars scale [5].
Table 2. Patient characteristics.
Table 3. Lesion characteristics between the two groups.
Table 4. Differences of initial and final VSS among each group of treatment.
Table 5. Comparison between topical and intra-lesional groups according to VSS and patient satisfaction.
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Abstract
Background

The Keloid is an elevated fibrous scar that may extend beyond the borders of the original wound.

Object

To compare between topical and intralesional mitomycin C in the treatment of auricular keloids.

Patients and methods

Prospective randomized study in which 40 patients with auricular keloids were included. The patients were divided into 2 groups, Group I included 32 patients who underwent topical mitomycin C application after the surgical removal of the auricular keloids, while Group II included 8 cases who underwent intra-lesional injection of mitomycin C after surgical removal of the auricular keloids.

Results

The two groups showed no significant difference regarding patient or lesion criteria (p>.05). VSS decreased significantly from 10.63 and 11.0 down to 1.38 and 3.0 after treatment in the topical and intra-lesional groups respectively (p<.001). However, greater improvement and satisfaction was detected in the topical group.

Conclusion

Both topical and intra-lesional mitomycin C injection are effective methods in managing auricular keloids. However, better VSS scores and patient satisfaction are reported with topical administration.

Keywords:
Keloid
Auricle
Mitomycin
Topical
Resumen
Antecedentes

El queloide es una cicatriz fibrosa elevada que puede extenderse más allá de los límites de la herida original.

Objetivo Comparar mitomicina C tópica frente a intralesional en el tratamiento de los queloides auriculares.

Pacientes y métodos

Estudio prospectivo aleatorio en el que se incluyó a 40 pacientes con queloides auriculares, que se dividieron en 2 grupos: el Grupo I incluyó 32 pacientes a quienes se aplicó mitomicina C tópica tras la resección quirúrgica de los queloides, y el Grupo II que incluyó 8 casos, a quienes se inyectó mitomicina C dentro de la lesión, tras la resección quirúrgica de los queloides auriculares.

Resultados

Los 2 grupos no reflejaron diferencia significativa en cuanto a criterios de pacientes o lesión (p>0,05). La escala de Vancouver (VSS) disminuyó significativamente de 10,63 y 11 a 1,38 y 3 tras el tratamiento en los grupos de aplicación tópica e intra-lesional, respectivamente (p<0,001). Sin embargo, se detectaron una mejora y satisfacción más altas en el grupo de aplicación tópica.

Conclusión

Las aplicaciones tópica e inyectada de mitomicina C son métodos efectivos para el tratamiento de queloides auriculares. Sin embargo, se reportaron mejores puntuaciones VSS y de satisfacción del paciente con la administración tópica.

Palabras clave:
Queloide
Aurícula
Mitomicina
Tópico

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