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Vol. 64. Issue 2.
Pages 150-153 (March - April 2013)
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Vol. 64. Issue 2.
Pages 150-153 (March - April 2013)
Case Study
DOI: 10.1016/j.otoeng.2013.04.010
Salivary Duct Carcinoma: Diagnostic Clues, Histology and Treatment
Carcinoma ductal salival: claves diagnósticas, histología y tratamiento
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Elena Ponta,??
Corresponding author
elenapont@hotmail.com

Corresponding author.
, Ángel Pláb, Julia Cruz Mojarrietac, Eduardo Ferrandisb, Simón Brotonsb, Juan B. Vendrellb
a Servicio de Otorrinolaringología, Hospital General de Castellón, Castellón, Spain
b Servicio de Otorrinolaringología, Fundación Instituto Valenciano de Oncología, Valencia, Spain
c Servicio de Anatomía Patológica, Fundación Instituto Valenciano de Oncología, Valencia, Spain
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Abstract

Salivary duct carcinoma is a very rare, highly malignant epithelial tumour. We present a case of a 75-year-old man with a rapidly growing salivary duct carcinoma in the parotid gland, of one month's evolution. Histopathologically, salivary duct carcinoma is characterised by its resemblance to ductal carcinoma of the breast. It usually develops aggressively with possibilities of early distant metastasis and local recurrence. The tumour is managed with total parotidectomy, ipsilateral neck dissection and adjunctive radiation. In advanced cases, we recommend treatment with anti-Her-2 monoclonal antibodies such as trastuzumab.

Keywords:
Salivary duct carcinoma
Salivary neoplasm
Resumen

El carcinoma ductal salival es un tumour epitelial de alto grado, muy poco frecuente. Presentamos el caso de un varón de 75 años con carcinoma ductal salival de rápido crecimiento, en la glándula parótida, de un mes de evolución. Histopatológicamente se caracteriza por su gran similitud con el carcinoma ductal de mama. Suele tener un comportamiento muy agresivo, con recurrencia local y metástasis a distancia tempranas, por lo que hay que realizar parotidectomía total con vaciamiento cervical ipsilateral y radioterapia adyuvante. En casos avanzados se recomienda tratamiento con anticuerpo monoclonal selectivo para el HER-2/neu como trastuzumab.

Palabras clave:
Carcinoma ductal salival
Neoplasias salivales

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