Buscar en
Acta Otorrinolaringológica Española
Toda la web
Inicio Acta Otorrinolaringológica Española Intestinal-type Sinonasal Adenocarcinomas. Immunohistochemical Profile of 66 Cas...
Journal Information
Vol. 64. Issue 2.
Pages 115-123 (March - April 2013)
Share
Share
Download PDF
More article options
ePub
Visits
2907
Vol. 64. Issue 2.
Pages 115-123 (March - April 2013)
Original Article
DOI: 10.1016/j.otoeng.2013.04.006
Intestinal-type Sinonasal Adenocarcinomas. Immunohistochemical Profile of 66 Cases
Adenocarcinomas nasosinusales tipo intestinal. Perfil inmunohistoquímico de 66 casos
Visits
...
Blanca Vivanco Allendea,??
Corresponding author
vivancoblanca@gmail.com

Corresponding author.
, Jhudit Perez-Escuredob, Nelson Fuentes Martíneza, Manuel F. Fresno Forcelledoa, José Luis Llorente Pendásb, Mario Hermsenb
a Departamento de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
b Departamento de Otorrinolaringología-Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (5)
Show moreShow less
Tables (2)
Table 1. Immunohistochemical Techniques Employed.
Table 2. Result of the Immunohistochemical Techniques Throughout the Entire Sample and Among the Different Histological Subtypes. Frequency (Percentage).
Show moreShow less
Abstract
Introduction and objectives

Intestinal-type sinonasal adenocarcinomas are malignant epithelial tumours. Around 8%–25% of all sinonasal malignant tumours are intestinal-type adenocarcinomas, which are related to wood dust exposure. Four histological subtypes have been described: papillary, colonic, solid and mucinous. We performed a pathological and immunohistochemical study in order to describe characteristics with prognostic, diagnostic and therapeutic value, and also to compare our results with previous studies.

Methods

Sixty-six tumour samples were analysed and protein expression of p53, p16, E-cadherin, β-catenin, epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2/neu) and cyclooxygenase-2 (COX-2) was performed by tissue microarray blocks.

Results

The 63% of cases were p53 positive; 37% showed nuclear staining with β-catenin and 100% with E-cadherin, while 98% showed membrane staining with β-catenin, 7% with EGFR, 8% with HER2/neu and 52% with COX-2; and 59% of the cases lost p16 expression.

Conclusions

Intracranial invasion was the worst prognostic associated event. Solid and mucinous tumours were the most aggressive histological subtypes. Intracranial invasion was more frequent in mucinous subtype tumours. Immunohistochemical results were similar in all tumour subtypes, except for mucinous tumours, which showed weak expression of E-cadherin and β-catenin. Comparing with previous studies, we found a lower expression of EGFR, HER2/neu and COX-2. The p16 expression was associated with worse survival and metastatic disease.

Keywords:
Sinonasal adenocarcinoma
Sinonasal carcinoma
Immunohistochemistry
p53
p16
β-Catenin
E-Cadherin
Epidermal growth factor receptor
Human epidermal growth factor receptor 2
Cyclooxygenase-2
Resumen
Introducción y objetivos

Los adenocarcinomas nasosinusales tipo intestinal son tumores epiteliales malignos, que suponen el 8–25% de los tumores malignos nasosinusales. Se relacionan con la exposición al polvo de la madera. Se subdividen histológicamente en papilares, colónicos, sólidos y mucinosos. Realizamos un estudio patológico e inmunohistoquímico con el fin de establecer características con significado pronóstico, diagnóstico e incluso terapéutico, así como comparar con estudios previos.

Métodos

Estudiamos 66 muestras tumorales mediante matrices tisulares. Realizamos tinciones inmunohistoquímicas para p53, p16, β-catenina, E-cadherina, receptor del factor de crecimiento epidérmico (EGFR), receptor 2 de factor de crecimiento epidérmico humano (HER2/neu) y ciclooxigenasa 2 (COX-2).

Resultados

Un 63% de los casos son positivos para p53, el 37% para β-catenina nuclear, el 100% para E-cadherina, el 98% para β-catenina membranosa, el 7% para EGFR, el 8% para HER2/neu, el 52% para COX-2 y el 59% pierden la expresión de p16.

Conclusiones

La invasión intracraneal es el factor clínico pronóstico más importante. Los tumores de tipo sólido y mucinoso son los que muestran un comportamiento más agresivo, siendo los mucinosos los que mayor invasión intracraneal muestran. No existen diferencias inmunohistoquímicas entre los distintos subtipos histológicos, únicamente la tinción débil para E-cadherina y β-catenina, más frecuente en los de tipo mucinoso. El EGFR, HER2/neu y COX-2 muestran una positividad menos frecuente que en series previas. La positividad para p16 se asocia a una menor supervivencia y mayor frecuencia de enfermedad metastásica.

Palabras clave:
Adenocarcinoma nasosinusal
Carcinoma nasosinusal
Inmunohistoquímica
p53
p16
β-catenina
E-cadherina
Receptor del factor de crecimiento epidérmico
Receptor 2 de factor de crecimiento epidérmico humano
Cyclooxigenasa-2

Article

These are the options to access the full texts of the publication Acta Otorrinolaringológica Española
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Acta Otorrinolaringológica Española

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos