Buscar en
Acta Otorrinolaringológica Española
Toda la web
Inicio Acta Otorrinolaringológica Española Impact of skin invasion on long-term survival outcomes in gingivobuccal complex ...
Journal Information
Vol. 72. Issue 4.
Pages 205-211 (July - August 2021)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 72. Issue 4.
Pages 205-211 (July - August 2021)
Original article
Impact of skin invasion on long-term survival outcomes in gingivobuccal complex carcinoma
Impacto de la invasión de la piel en los resultados de supervivencia a largo plazo en el carcinoma del complejo gingivobuccal
Visits
...
Smriti Pandaa, Rajeev Kumara,
Corresponding author
rajeev9843@yahoo.co.in

Corresponding author.
, Ashwin Chandran Ca, Alok Thakara, Suresh C. Sharmaa, Suman Bhaskerb, Atul Sharmac
a Department of Otolaryngology, All India Institute of Medical Sciences, New Delhi, India
b Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India
c Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (6)
Table 1. Summary of patient characteristics.
Table 2. Survival outcomes for various subsites.
Table 3. Survival analysis for T4 tumours.
Table 4. 3 year survival analysis for different prognostic variables.
Table 5. A. Univariate and multivariate analysis (Cox Proportional Hazard Model) for Overall Survival.
Table 6. Literature review of factors affecting survival outcomes in gingivobuccal complex carcinomas.
Show moreShow less
Abstract
Introduction

Gingivo-buccal complex cancers (GBCC) have an aggressive clinical course in the presence of skin and bone involvement.

Objective

This study intends to analyze the clinico-pathological factors affecting local control and survival outcomes in GBCC.

Methods

This is a retrospective study conducted on 125 GBCC cases from January 2011 to April 2016.

Result

Univariate analysis revealed lymphovascular invasion (LVI) and skin involvement as predictors of poor overall survival (OS) and disease- free survival (DFS). Multivariate analysis showed skin involvement and LVI to be independent prognostic factors towards poor OS. Corresponding results in case of DFS showed skin involvement to be the single most important prognostic factor. With a median follow up of 24 months, the median survival of patients with skin involvement, skin and mandible invasion and isolated mandible invasion, respectively, were 18 months, 12 months and 22 months.

Conclusion

GBCC with skin involvement portends poor outcome in terms of survival. In the presence of skin invasion, treatment entails liberal soft tissue and bone margin followed by adjuvant treatment.

Keywords:
Gingivobuccal complex
Prognosis
Survival outcome
Skin involvement
Mandible involvement
Resumen
Introducción

Los cánceres del complejo gingivo-bucal (GBCC) tienen un curso clínico agresivo en presencia de afectación de la piel y los huesos.

Objetivo

Este estudio pretende analizar los factores clínico-patológicos que afectan al control local y los resultados de supervivencia en GBCC.

Métodos

Este es un estudio retrospectivo realizado en 125 casos de GBCC desde enero del 2011 hasta abril del 2016.

Resultado

El análisis univariado reveló la invasión linfovascular (LVI) y la afectación de la piel como predictores de una supervivencia general pobre (SG) y una supervivencia libre de enfermedad (SSE). El análisis multivariado mostró que la afectación de la piel y el LVI son factores pronósticos independientes hacia una SG pobre. Los resultados correspondientes en caso de SSE mostraron que la afectación de la piel es el factor pronóstico más importante. Con una mediana de seguimiento de 24 meses, la mediana de supervivencia de pacientes con afectación cutánea, invasión de la piel y la mandíbula e invasión aislada de la mandíbula, respectivamente, fue de 18 meses, 12 meses y 22 meses.

Conclusión

El GBCC con afectación de la piel presagia un mal resultado en términos de supervivencia. En presencia de invasión de la piel, el tratamiento implica unos márgenes de tejidos blandos y oseos amplios seguido de un tratamiento adyuvante.

Palabras clave:
Complejo gingivo-bucal
Pronóstico
Supervivencia
Afectación de la piel
Participación de la mandíbula

Article

These are the options to access the full texts of the publication Acta Otorrinolaringológica Española
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Acta Otorrinolaringológica Española

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos