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Vol. 72. Issue 4.
Pages 205-211 (July - August 2021)
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Vol. 72. Issue 4.
Pages 205-211 (July - August 2021)
Original article
Impact of skin invasion on long-term survival outcomes in gingivobuccal complex carcinoma
Impacto de la invasión de la piel en los resultados de supervivencia a largo plazo en el carcinoma del complejo gingivobuccal
Smriti Pandaa, Rajeev Kumara,
Corresponding author

Corresponding author.
, Ashwin Chandran Ca, Alok Thakara, Suresh C. Sharmaa, Suman Bhaskerb, Atul Sharmac
a Department of Otolaryngology, All India Institute of Medical Sciences, New Delhi, India
b Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India
c Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
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Figures (1)
Tables (6)
Table 1. Summary of patient characteristics.
Table 2. Survival outcomes for various subsites.
Table 3. Survival analysis for T4 tumours.
Table 4. 3 year survival analysis for different prognostic variables.
Table 5. A. Univariate and multivariate analysis (Cox Proportional Hazard Model) for Overall Survival.
Table 6. Literature review of factors affecting survival outcomes in gingivobuccal complex carcinomas.
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Gingivo-buccal complex cancers (GBCC) have an aggressive clinical course in the presence of skin and bone involvement.


This study intends to analyze the clinico-pathological factors affecting local control and survival outcomes in GBCC.


This is a retrospective study conducted on 125 GBCC cases from January 2011 to April 2016.


Univariate analysis revealed lymphovascular invasion (LVI) and skin involvement as predictors of poor overall survival (OS) and disease- free survival (DFS). Multivariate analysis showed skin involvement and LVI to be independent prognostic factors towards poor OS. Corresponding results in case of DFS showed skin involvement to be the single most important prognostic factor. With a median follow up of 24 months, the median survival of patients with skin involvement, skin and mandible invasion and isolated mandible invasion, respectively, were 18 months, 12 months and 22 months.


GBCC with skin involvement portends poor outcome in terms of survival. In the presence of skin invasion, treatment entails liberal soft tissue and bone margin followed by adjuvant treatment.

Gingivobuccal complex
Survival outcome
Skin involvement
Mandible involvement

Los cánceres del complejo gingivo-bucal (GBCC) tienen un curso clínico agresivo en presencia de afectación de la piel y los huesos.


Este estudio pretende analizar los factores clínico-patológicos que afectan al control local y los resultados de supervivencia en GBCC.


Este es un estudio retrospectivo realizado en 125 casos de GBCC desde enero del 2011 hasta abril del 2016.


El análisis univariado reveló la invasión linfovascular (LVI) y la afectación de la piel como predictores de una supervivencia general pobre (SG) y una supervivencia libre de enfermedad (SSE). El análisis multivariado mostró que la afectación de la piel y el LVI son factores pronósticos independientes hacia una SG pobre. Los resultados correspondientes en caso de SSE mostraron que la afectación de la piel es el factor pronóstico más importante. Con una mediana de seguimiento de 24 meses, la mediana de supervivencia de pacientes con afectación cutánea, invasión de la piel y la mandíbula e invasión aislada de la mandíbula, respectivamente, fue de 18 meses, 12 meses y 22 meses.


El GBCC con afectación de la piel presagia un mal resultado en términos de supervivencia. En presencia de invasión de la piel, el tratamiento implica unos márgenes de tejidos blandos y oseos amplios seguido de un tratamiento adyuvante.

Palabras clave:
Complejo gingivo-bucal
Afectación de la piel
Participación de la mandíbula


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