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Vol. 74. Issue 5.
Pages 277-282 (September - October 2023)
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Vol. 74. Issue 5.
Pages 277-282 (September - October 2023)
Original article
Evaluation of von Willebrand factor and protein/creatinine ratio in idiopathic sudden hearing loss
Evaluación del Factor Von Willebraund y la Relación Proteína/Creatinina en la Hipoacusia Súbita Idiopática
Özge Çaglar Çila,
Corresponding author

Corresponding author.
, Serkan Bakirdögenb, Dilek Ülker Çakirc, Hasan Gülc, Sibel Oymakd
a Canakkale 18 March University, Medical School, Otorhinolaryngology Department, Turkey
b Canakkale 18 March University, Medical School, Nephrology Department, Turkey
c Canakkale 18 March University, Medical School, Biochemistry Department, Turkey
d Canakkale 18 March University, Medical School, Public Health Department, Turkey
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Tables (4)
Table 1. Distribution of categorical variables across groups in our study group.
Table 2. Comparison of variables among groups in our study group.
Table 3. Comparison of patient groups responding and not responding to treatment.
Table 4. Relationship between protein/creatinine ratio with VWF and post-treatment hearing test averages in patients with sudden hearing loss.
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The objective of this study was to evaluate the levels of von Willebraund Factor (vWF) in plasma and the protein/creatinine ratio in urine in patients with idiopathic sudden acute hearing loss, which we think to be caused by epithelial dysfunction.


Thirty patients with a sudden hearing loss and thirty healthy individuals were included in the study. Before the treatment, blood and urine were collected from the patients and the control group to investigate the levels of the protein/creatinine ratio and the levels of vWF. The test results of the patients group were compared with those of the control group.


We found that the levels of vWF increased in the patient group, which was statistically significant (P<.05). The protein/creatinine ratio in the urine increased in the patient group, but this was not statistically significant (P>.05). In addition, we found that the vWF and urine protein/creatin ratio of the patients who benefited from treatment were lower than those who did not benefit.


This study showed that sudden sensorineural hearing loss may result from endothelial dysfunction. However, more studies that include more patients are needed in order to support this.

Sensorineural hearing loss
Protein/creatinine ratio
List of abbreviations:

El objetivo de este estudio fue evaluar los niveles de factor de von Willebraund (vWF) en plasma y la relación proteína/creatinina en orina en pacientes con hipoacusia aguda súbita idiopática, que creemos que es causada por una disfunción epitelial.


Treinta pacientes con hipoacusia súbita y treinta individuos sanos fueron incluidos en el estudio. Antes del tratamiento, se recogieron sangre y orina de los pacientes y del grupo de control para investigar los niveles de relación proteína/creatinina y los niveles de vWF. Los resultados de las pruebas del grupo de pacientes se compararon con el grupo de control.


En la literatura, se sabe que la cantidad de proteína en la orina y las elevaciones en los niveles de vWF en plasma son las consecuencias de la disfunción endotelial. Encontramos que los niveles de vWF aumentaron en el grupo de pacientes y esto fue estadísticamente significativo. Sin embargo, la relación proteína/creatinina en la orina aumentó en el grupo de pacientes, pero esto no fue estadísticamente significativo. Además, encontramos que el vWF y la relación proteína/creatina en orina de los pacientes que se beneficiaron del tratamiento fueron más bajos que los que no se beneficiaron.


Este estudio muestra que la pérdida auditiva neurosensorial súbita puede resultar de una disfunción endotelial. Sin embargo, se necesitan más estudios que incluyan más pacientes para respaldar esto.

Palabras clave:
Hipoacusia neurosensorial
Cociente proteína/creatinine


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