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Vol. 71. Issue 1.
Pages 40-44 (January - February 2020)
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Vol. 71. Issue 1.
Pages 40-44 (January - February 2020)
Brief communication
Clinical Use of 4-aminopyridine in Patients With Downbeat Nystagmus
Experiencia de uso de fampridina en pacientes con nistagmo vertical inferior
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Emilio Domínguez-Durána,
Corresponding author
emiliodominguezorl@gmail.com

Corresponding author.
, Irene Mármol-Szombathya, Úrsula Baños-Roldánb, Serafín Sánchez-Gómeza
a Unidad de Gestión Clínica de Otorrinolaringología, Hospital Universitario Virgen Macarena, Sevilla, Spain
b Unidad de Gestión Clínica de Farmacia Hospitalaria, Hospital Universitario Virgen Macarena, Sevilla, Spain
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Table 1. Patient Characteristics Presented in This Publication.
Abstract
Objective

To present the results of treatment with sustained-release fampridine (4-AP-SR) in patients with downbeat nystagmus.

Material and method

Series of cases with downbeat nystagmus treated with 10mg of 4-AP-SR every 12h. The clinical improvement and the variation of the nystagmus before and after the treatment were evaluated, recording the score in the Dizziness Handicap Inventory (DHI), the velocity of the slow phase of the nystagmus and its frequency.

Results

Three patients were treated, none of whom reported significant subjective changes during the treatment. No significant differences were detected in the Dizziness Handicap Inventory score or in the studied videonystagmographic variables.

Conclusion

This communication does not present positive results on the use of 4-AP-SR. The contradiction with previous studies may be caused by a small sample size, by the aetiology of the cases or by the way in which the results were measured.

Keywords:
Downbeat nystagmus
Fampridine
Resumen
Objetivo

Presentar los resultados del tratamiento con fampridina de liberación prolongada (4-AP-SR) en pacientes con nistagmo vertical inferior.

Material y método

Serie de casos de nistagmo vertical inferior tratados con 10mg de 4-AP-SR cada 12h. Se valoraron la mejoría clínica y la variación del nistagmo antes y después del tratamiento, registrando la puntuación en el Dizziness Handicap Inventory, la velocidad de la fase lenta del nistagmo y su frecuencia.

Resultados

Se trataron 3 pacientes, ninguno de los cuales notó cambios durante el tratamiento en relación con los síntomas visuales, aunque 2 pacientes notaron mejoría subjetiva de la marcha. No se detectaron diferencias significativas en la puntuación del Dizziness Handicap Inventory ni en las variables videonistagmográficas estudiadas.

Conclusión

No se han detectado cambios en los síntomas visuales con el tratamiento con 4-AP-SR. La contradicción con estudios previos puede estar producida por un bajo tamaño muestral, la etiología de los casos o la forma de medir los resultados.

Palabras clave:
Nistagmo vertical inferior
Fampridina

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