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Inicio Acta Otorrinolaringológica Española A Comparative Study on Efficacy of Glucocorticoids, Mineralocorticoids and Vasoa...
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Vol. 66. Issue 2.
Pages 65-73 (March - April 2015)
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Vol. 66. Issue 2.
Pages 65-73 (March - April 2015)
Original article
A Comparative Study on Efficacy of Glucocorticoids, Mineralocorticoids and Vasoactive Drugs on Reversing Hearing Loss in Patients Suffering Idiopathic Sensorineural Cochlear Hypoacusis. A Preliminary Clinical Trial
Estudio comparativo de la eficacia de los glucocorticoides, mineralocorticoides y vasodilatadores en la recuperación auditiva de pacientes que padecen hipoacusia neurosensorial idiopática de localización coclear. Ensayo clínico preliminar
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Eugenia María Campos-Bañalesa,
Corresponding author
emcampos@ull.es

Corresponding author.
, Daniel López-Camposb, José Luis de Serdio-Ariasc, J. Esteban-Rodriguezc, Mar García-Sáinzd, Álvaro Muñoz-Cortésd, Daniel López-Aguadoa
a Associate Professor of Otolaryngology, Facultad de Medicina, La Laguna, Spain
b Servicio de Otorrinolaringología. Departamento de Cirugía, Hospital Universitario de Canarias, Spain
c Servicio de Otorrinolaringología, Departamento de Cirugía, Hospital Universitario Nuestra Señora de Candelaria, Spain
d Servicio de Farmacología Clínica, Departamento de Medicina Física y Farmacología, Hospital Universitario de Canarias, Spain
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Figures (9)
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Tables (4)
Table 1. Distribution of Patients According to Age.
Table 2. Mean Hearing Loss (Detailed and Total) Presented by the Patients in Both Ears.
Table 3. Mean Hearing Gain Achieved in Each Ear at the End of the Trial, According to the Drug Used.
Table 4. Comparison of Final Hearing Gains According to Gender, Ear Studies and Drug Used. Bonferroni's Method.
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Abstract
Introduction and objectives

Sensory neural hearing loss (SNHL) is a disorder characterized by an important deterioration of the auditory function. Re-establishing normal ion homeostasis of the endolymph could be related to hearing recovery and it might be mediated by mineralocorticoids.

The main purpose of this preliminary, randomized controlled clinical trial was assessing the recovery of idiopathic sensory neural cochlear hearing loss (SNHL) by comparing the efficacy of 2 types of steroids versus vasodilators.

Materials and Methods

The 3-month intervention involved 70 patients, allocated into 4 different groups: a control with no medication, consisting of 14 patients (8 men and 6 women); a vasodilator group of 21 patients (11 men and 10 women); a glucocorticoid group with 16 patients (10 men and 6 women); and a mineralocorticoid therapy group, consisting of 19 patients (11 men and 8 women). The level of hearing loss and its topography were estimated using Liminal Tone Audiometry (LTA) and Auditory Brainstem Response (ABR).

Results

Our research found overall greater efficacy of mineralocorticoids versus glucocorticoids and vasodilators. There was better response in women than in men and it was higher from the left ear, regardless of patient gender.

Conclusions

The hearing gain was significantly superior in the mineralocorticoid group, followed by the glucocorticoid group. However, the responses to vasodilators were lesser and of low statistical significance.

Keywords:
Idiopathic sensorineural cochlear hearing loss
Liminal tonal audiometry
Auditory brainstem response
Resumen
Introducción y objetivos

La hipoacusia neurosensorial (HNS) puede conducir a causar grave deterioro auditivo. Su recuperación funcional parece relacionarse con el control de la homeostasis iónica coclear experimentalmente dependiente de los mineralocorticoides.

El objetivo de este trabajo es valorar la eficacia terapéutica comparando 2 modalidades de corticoides frente a los vasodilatadores en pacientes con HNS idopática coclear (HNSIC).

Material y métodos

El ensayo dura 3 meses, se realiza en 70 pacientes asignados aleatoriamente en 4 grupos: grupo control, sin medicación, formado por 14 pacientes (8 varones y 6 mujeres); grupo tratado con vasodilatadores formado por 21 pacientes (11 hombres y 10 mujeres); grupo sometido a terapia glucocorticoidea formado por 16 pacientes (10 varones y 6 mujeres); y grupo sometido a terapia mineralocorticoidea formado por 19 pacientes (11 varones y 8 mujeres). La valoración del nivel de pérdida auditiva y su topografía se estiman mediante audiometría tonal liminal (ATL) y potenciales auditivos de tronco cerebral (PEATC).

Resultados

Encontramos mejor respuesta al tratamiento con los mineralocorticoides que con los glucocorticoides, siendo la respuesta más pobre para los vasodilatadores. Esta respuesta es mayor en las mujeres que en los hombres, y en general observamos mejor respuesta por parte del oído izquierdo, con independencia del sexo del paciente.

Conclusiones

Las ganancias auditivas son significativamente mayores con los mineralocorticoides, seguidas por los glucocorticoides, mientras que con los vasodilatadores las respuestas son pobres y no significativas.

Palabras clave:
Hipoacusia neurosensorial idiopática coclear
Audiometría tonal liminal
Potencial auditivo de tronco cerebral

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