ISSN: 2173-5808

Neurología, founded in 1986, is the official scientific Journal of the Spanish Neurology Society (Sociedad Española de Neurología, SEN). It is edited by Dr. Jorge Matías-Guiu and is indexed in the most important international data bases, such as Science Citation Index or Index Medicus/MEDLINE. The Journal accepts works on basic as well applied research on any field of neurology.

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Abstract
Keywords
Resumen
Palabras clave
Introduction
Materials and methods
Animal preparation
Experimental design and treatment
Statistical analysis
Results
Bcp inhibits mptp-induced th immunoreactivity loss in str and sn
β-caryophyllene inhibits mptp-induced microglia cell density in the str and sn
Effect of bcp on the mptp-induced astrocyte cell density in the str and sn
Effects of bcp on the mptp-induced reduction of th expression and augmentation of iba1 and gfap
Bcp inhibits mptp-induced tight junction protein depletion and blood–brain barrier disruption
Effect of bcp on the mptp-induced lipid peroxidation in mice
Nrf2 nuclear/cytoplasmatic expression in the str
Nqo1 expression in the str
Discussion
Cellular level
Bbb and tight junction proteins
Oxidative stress and nrf2
Peroxisome proliferator-activated receptor γ ppar-γ
Conclusions
Funding
Conflicts of interest
Acknowledgments
Bibliography

Original article

DOI: 10.1016/j.nrleng.2025.02.003

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Beta-caryophyllene inhibits the permeability of the blood–brain barrier in MPTP-induced parkinsonism

El beta-cariofileno inhibe la permeabilidad de la barrera hematoencefálica en el parkinsonismo inducido por MPTP

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A.R. Ramos-Molinaa,b, A.R. Tejeda-Martínezb, J.M. Viveros-Paredesc, V. Chaparro-Huertab, M.F. Urmeneta-Ortíza, L.J. Ramírez-Jiranod, M.E. Flores-Sotob,

a Centro Universitario de los Lagos, Universidad de Guadalajara, Lagos de Moreno, Jalisco, Mexico

b Laboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico

c Laboratorio de Investigación y Desarrollo Farmacéutico, Departamento de Farmacología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

d División de Neurociencias, Centro de Investigación Biomédica Occidente (IMSS), Guadalajara, Mexico

Article

This article is available in English

Beta-caryophyllene inhibits the permeability of the blood–brain barrier in MPTP-induced parkinsonism

A.R. Ramos-Molina, A.R. Tejeda-Martínez, J.M. Viveros-Paredes, V. Chaparro-Huerta, M.F. Urmeneta-Ortíz, L.J. Ramírez-Jirano, M.E. Flores-Soto

10.1016/j.nrleng.2025.02.003

Neurologia. 2025;40:191-203

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Beta-caryophyllene inhibits the permeability of the blood–brain barrier in MPTP-induced parkinsonism

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