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Distribución y función de los receptores alfaadrenérgicos del músculo liso vascular
Distribution and function of alpha adrenergic receptors in vascular smooth muscle
B. Civantos Calzada, A. Aleixandre de Artiñano
Autor para correspondencia
amaya@med.ucm.esr

Correspondencia: A. Aleixandre de Artiñano. Departamento de Farmacología. Facultad de Medicina. Universidad Complutense Madrid. Ciudad Universitaria, s/n. 28040 Madrid.
Departamento de Farmacología. Facultad de Medicina. Universidad Complutense de Madrid
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En la d&#233;cada de los setenta se estableci&#243; la existencia de dos tipos de receptores alfaadren&#233;rgicos&#59; los &#945;1 y los &#945;2&#46; El receptor &#945;1 usualmente media las respuestas en el &#243;rgano efector&#44; y el receptor &#945;2 se localiza presin&#225;pticamente y regula la liberaci&#243;n del neurotransmisor&#46; Sin embargo&#44; el receptor &#945;2 tambi&#233;n aparece a nivel postsin&#225;ptico y coexiste en el m&#250;sculo liso vascular con el receptor &#945;2&#46; Ambos receptores &#945;son importantes para el control del tono vascular&#44; y de ellos nos ocuparemos en esta revisi&#243;n&#46; Hoy se sabe que los receptores &#945;1 y los &#945;2 no representan poblaciones homog&#233;neas y se pueden subdividir unos y otros en distintos subtipos&#46; Actualmente la clasificaci&#243;n de los receptores &#945;1-adren&#233;rgicos ha quedado establecida de la siguiente manera&#58; subtipo &#945;1A &#40;clonado &#945;1c y nombrado provisionalmente por algunos investigadores &#945;1a&#47;c&#41;&#44; subtipo &#945;1B &#40;clonado &#945;1b&#41; y subtipo &#945;1D &#40;clonado &#945;1d y nombrado provisionalmente por algunos investigadores &#945;1a&#47;d&#41;&#46; Parece que el subtipo &#945;1A estar&#237;a m&#225;s implicado en el mantenimiento del tono basal y la tensi&#243;n arterial en animales conscientes y&#44; sin embargo&#44; los subtipos &#945;1B y &#945;1D probablemente participan m&#225;s en la respuesta de los agonistas&#46; Se ha estudiado sobre todo la regulaci&#243;n de la expresi&#243;n del subtipo &#945;1B porque se sabe que la expresi&#243;n de este receptor puede alterarse en situaciones patol&#243;gicas&#46; Actualmente la clasificaci&#243;n de los receptores &#945;2-adren&#233;rgicos ha quedado establecida de la siguiente manera&#58; subtipo &#945;2A&#47;D &#40;hoy se acepta que el subtipo &#945;2A y el subtipo &#945;2D son el mismo receptor identificado en diferentes especies&#58; el &#945;2A en el hombre y el &#945;2D en la rata&#41;&#44; subtipo &#945;2B &#40;clonado &#945;2b&#41; y subtipo &#945;2C &#40;clonado &#945;2c&#41;&#46; Hoy se sabe que el subtipo &#945;2A&#47;D y el &#945;2B controlan la contracci&#243;n arterial y que el subtipo &#945;2C es sobre todo responsable de la vasoconstricci&#243;n venosa&#46; Tambi&#233;n se sabe que el subtipo &#945;2A&#47;D media fundamentalmente los efectos centrales de los agonistas &#945;2&#46;</p>"
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Información del artículo
ISSN: 18891837
Idioma original: Español
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