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Inicio Medicina Clínica (English Edition) Value of the tumor inhibitor of cellular immunity PDL-1 in the incidence of veno...
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Vol. 162. Issue 9.
Pages 425-427 (May 2024)
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Vol. 162. Issue 9.
Pages 425-427 (May 2024)
Original article
Value of the tumor inhibitor of cellular immunity PDL-1 in the incidence of venous thrombosis in patients with gastric cancer
Valor del inhibidor tumoral de la inmunidad celular PDL-1 en la incidencia de trombosis venosa en pacientes con cáncer gástrico
Margarita Lorentea, Kevin Doelloa,b,
Corresponding author
kevindoello@gmail.com

Corresponding author.
a Servicio de Oncología Médica, Hospital Virgen de las Nieves, Granada, Spain
b Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain
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Tables (3)
Table 1. Descriptive statistics (absolute and relative frequencies) on the oncological characteristics of the patients studied.
Table 2. Descriptive statistics (absolute and relative frequencies) on the characteristics of venous thrombosis in the patients studied.
Table 3. Summary table of the relative and absolute frequency of occurrence of venous thromboembolic events stratified by the different variables analyzed.
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Abstract
Introduction

Gastric cancer is one of the cancers most associated with thromboembolic phenomena. The objective of this article is to study if there is a correlation between thromboembolic phenomena in gastric cancer and tumor expression of PDL-1.

Methods

To this end, the association between thromboembolic events and PDL-1 expression was retrospectively studied in a sample of 46 patients from our hospital.

Results

The results obtained revealed a statistically significant difference between the percentage of thromboembolic events between positive and negative PDL-1 with an increase in the latter with a P value of 0.034.

Conclusion

In conclusion, the expression of PDL-1, and with it, of an inhibitory factor of the cellular immune response, correlates with a decrease in thromboembolic events in patients with gastric cancer, which could indicate the crucial role of the immune response in which thromboembolic events occur.

Keywords:
Gastric cancer
Cellular immunity
Thromboembolic events
PDL-1
Resumen
Introducción

El cáncer gástrico es uno de los cánceres más asociados a fenómenos tromboembólicos. El objetivo de este artículo es estudiar si existe correlación entre los fenómenos tromboembólicos en el cáncer gástrico y la expresión tumoral de PDL-1.

Métodos

Para ello, se estudió retrospectivamente la asociación entre eventos tromboembólicos y la expresión de PDL-1 en una muestra de 46 pacientes de nuestro hospital.

Resultados

Los resultados obtenidos revelaron una diferencia estadísticamente significativa entre el porcentaje de eventos tromboembólicos entre PDL-1 positivo y negativo con un aumento en este último con un valor P de 0,034.

Conclusión

La expresión de PDL-1, y con ella, de un factor inhibidor de la respuesta inmune celular, se correlaciona con una disminución de los eventos tromboembólicos en pacientes con cáncer gástrico, lo que podría indicar el papel crucial de la respuesta inmune en la ocurrencia de eventos tromboembólicos.

Palabras clave:
Cáncer gástrico
Inmunidad celular
Eventos tromboembólicos
PDL-1

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