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Inicio Medicina Clínica (English Edition) Cardiovascular risk assessment with carotid ultrasound in rheumatoid arthritis
Journal Information
Vol. 159. Issue 10.
Pages 470-474 (November 2022)
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Vol. 159. Issue 10.
Pages 470-474 (November 2022)
Original article
Cardiovascular risk assessment with carotid ultrasound in rheumatoid arthritis
Evaluación del riesgo cardiovascular en pacientes con artritis reumatoide mediante ecografía carotídea
Roxana González Mazaríoa,b, Jorge Juan Fragío Gila,b,c,
Corresponding author
jorgefragio@gmail.com

Corresponding author.
, Pablo Martínez Calabuigd, Elena Grau Garcíaa, Antonio José Cañada Martínezc,e, José Andrés Román Ivorraa,b,d
a Servicio de Reumatología, Hospital Universitari i Politècnic La Fe, Valencia, Spain
b Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain
c Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain
d Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain
e Unidad de Bioestadística, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain
Article information
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Abstract
Background/Objective

To assess the Cardiovascular Risk (CV) in Rheumatoid Arthritis (RA) patients using carotid ultrasound additionally to the traditional CV risk factors.

Methods

A cross-sectional case control study was performed including RA patients and matched controls. This study was performed from July-2019 to January-2020. Population over 75 years old, established CV disease and/or chronic kidney disease (from III Stage) were excluded. Statistical analysis included a multivariate variance analysis (Manova) and a negative binomial regression adjusted by confounding factors.

Results

Overall, a total of 200 cases and 111 controls were included in the study. Demographical and clinical variables were comparable between groups. A relationship between age, BMI and high blood pressure was detected in both groups. RA patients showed higher intima-media thickness and higher plaque account compared to controls and it was related to the disease duration and DAS28 score.

Conclusion

RA leads to a higher intima-media thickness, and this is related to the disease duration and DAS28 score. These findings support that RA acts as an independent cardiovascular risk factor.

Keywords:
Rheumatoid arthritis
Cardiovascular risk
Carotid ultrasound
Resumen
Objetivo

Evaluar el riesgo cardiovascular (RCV) en pacientes con artritis reumatoide (AR) mediante el empleo de la ecografía de carótidas en adición a los factores de riesgo cardiovascular clásicos.

Métodos

Se realizó un estudio de casos y controles transversal incluyendo pacientes con AR y controles voluntarios sin historia de eventos cardiovasculares. El estudio se llevó a cabo entre julio de 2019 y enero de 2020. Se excluyeron individuos con edad por encima de los 75 años, enfermedad cardiovascular establecida y/o enfermedad renal crónica.

Resultados

En total, se incluyeron 200 pacientes con AR y 111 controles. Las variables demográficas y clínicas fueron comparables entre los grupos de estudio. Se halló correlación entre la edad, el IMC y la presencia de hipertensión arterial en ambos grupos. Los pacientes con AR evidenciaron un mayor grosor íntima-media y una mayor presencia de placas en el estudio de ecografía carotídea respecto a los controles y además demostró guardar relación con una mayor duración de la enfermedad.

Conclusiones

La AR conlleva el desarrollo de un mayor grosor íntima-media y ello correlaciona con la duración y la actividad de la enfermedad, lo cual apoya que la AR actúa como un factor de riesgo cardiovascular independiente.

Palabras clave:
Artritis reumatoide
Riesgo cardiovascular
Ecografía carotídea

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