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Individuals previously infected with SARS-CoV-2 ancestral strain do not develop neutralizing antibodies against the Omicron variant.
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Omicron variant escapes immune response after SARS CoV-2 previous infection with the SARS CoV-2 Gamma variant.
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Individuals previously infected with SARS-CoV-2 ancestral strain or with SARS-CoV-2 Gamma variant will likely have little protection if subsequently exposed to the Omicron variant.