Fetal arterial Doppler-IUGR and hypoxia

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Abstract

Vascular resistances of various fetal arreas are assessed by Doppler ultrasound. The PI, RI and S/D indices are measured on the cerebral, renal, aortic and umbilical Doppler spectrum. Ratios of these indices based on the comparison of the cerebral (Rc) and the umbilical (Rp) resistances, or carotid (Rcc) and umbilical resistances, or cerebral (Rc) and aortic (Rao) resistances (Rc.Rp or Rp/Rcc, or Rc/Rao), measure the flow redistribution between the placenta and brain. The umbilical resistance indices, when greater than the upper limit of the normal range (>2sd) are frequently associated with IUGR. (Sensitivity about 65 to 70%). Absent end diastolic flow is most of the time associated with severe IUGR and hypoxia and poor fetal outcome. A fairly good correlation was found between the existence of significantly decrerased (<.2sd) cerebral resistance and the development of post asphyxial encephalopathy in the neonate (Specificity 75% Sensitivity 87%). The earliest detectors of IUGR and hypoxia are the cerebral-umbilical cerebral-carotid, or cerebral-aortic ratios (Sensitivity 85% specificity 90%). When used as predictor of poor perinatal outcome in growth retarded fetuses, the cerebral umbilical ratio shows a sensitivity of 90% compared with 78% of the middle cerebral artery, and 83% for the umbilical artery indices. Changes of this ratio are well correlated with the fetal pO2 changes. The renal flow response to hypoxia depends on the degree of hypoxia. Opposite responses were found in case of moderate, and severe IUGR or hypoxia. Thus, it is too early to conclude if the renal indices are reliable parameters for the evaluation of fetal hypoxia. The sensitivity in predicting IUGR was for the aortic PI: 41% and for the aortic BFC (Blood flow classes): 57%. In predicting delivery for fetal distress, the corresponding values were 76 and 87%, respectively. Because the resistance indices are heart rate-dependent, it is dangerous to draw any conclusion from one single value of any of these parameters. Only several successive measurement of the Doppler indices or of their ratio, may lead to a reliable evaluation of fetal hemodynamics. In the case of significant IUGR with abnormal Doppler indices it is recommended to repeat the Doppler measurements daily both at the cerebral and umbilical or aortic level in order to follow up the fetal flow redistribution which is highly correlated with the fetal pO2 changes.

Section snippets

Peripheral fetal flow assessment

In order to quantify the vascular resistances, various indices which measure the proportion of systolic flow within the total forward flow (M) during one cardiac cycle, or the relative amplitude of systolic (S) to diastolic (D) flow, have been proposed. Most of these parameters change with the resistance to flow into the vascular territory investigated (PI=SD/M,RI=SD/S,R=S/D,R=D/S). Increased vascular resistance may be due to vascular disease (placental infarction or fibrosis) or to distal

Umbilical circulation

The umbilical vascular resistance indices, when greater than the upper limit of the normal range (>2xS.D.) are frequently associated with IUGR. The sensitivity of this method in this application is generally about 65 to 70%. Several authors have shown that when used as a predictor of fetal well-being, only strong disturbances of the umbilical arterial flow such as absent end diastolic flow, are frequently associated with acute fetal patency, but in this case it is still difficult to evaluate

Recommendations and perspectives

Fetal Doppler indices were initially developed for the detection of IUGR and fetal hypoxia, and used in case of suspicion of severe fetal growth retardation and poor fetal outcome. Subsequently combinations of Doppler cerebral and umbilical or aortic indices were used to make the method more sensitive. Thus many obstetricians integrated these Doppler indices into the management process of the pregnancy.

Nevertheless, because the resistance indices are heart rate-dependent, it is dangerous to

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