PaperThe effect of age and weight on the response to formalin inactivated, alum-adjuvanted hepatitis A vaccine in healthy adults
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Cited by (72)
Obesity, immunity and vaccination
2021, VacunasUse of hepatitis A vaccine for post-exposure prophylaxis in individuals over 40 years of age: A systematic review of published studies and recommendations for vaccine use
2018, VaccineCitation Excerpt :At 30 days post-vaccination, however, 97% of individuals in both groups had seroconverted. Reuman et al., which used a lower dose of VAQTA than currently recommended for adults in the U.S., also found somewhat lower responses in the older age group two weeks after vaccination [17]. In the <40 year age group, 56% of individuals seroconverted (n = 50; P = 0.017) at two weeks post-vaccination compared with only 31% in the ≥40 year age group (n = 45).
Hepatitis A Vaccines
2017, Plotkin's VaccinesRubella seronegativity in antenatal screening - Is it influenced by the introduction of universal childhood rubella immunization?
2015, VaccineCitation Excerpt :The immune response to childhood rubella vaccination can be influenced by age at vaccination, as rubella seropositivity was highest in children aged 6–11 years (96.2%), followed by children aged 12–19 years (93.7%), and lowest in adult women (88.9–91.5) in the US where vaccination coverage is >90% [32]. Aging impairs T-cell function [33–35], and together with factors like overweight, gender, and vaccine regimen, all influence the individual's response to vaccines such as hepatitis A vaccine [36] and combined hepatitis A/B vaccine [37]. Therefore advanced age, high BMI, and vaccine regimen, have to be included in our analysis.
The weight of obesity on the human immune response to vaccination
2015, VaccineCitation Excerpt :Elevated BMI was identified as the most significant factor correlated with a significant decline (p < 0.05) in anti-HAV titers and the third most significant factor for poor vaccine-induced anti-HBs titers. Another study [44] observed a slower antibody response to HAV vaccination in overweight individuals, despite an increase in antibody response after a second booster dose. When anti-HAV titers were measured four weeks post-vaccination, both weight (p = 0.019) and BMI (p = 0.016) were significant predictors of non-protective (anti-HAV titers < 10 mIU/mL) seroresponse, with the odds of being a responder increasing as weight and BMI decreased.
An outbreak of hepatitis A virus associated with a multi-national inner-city nursery in Glasgow, Scotland
2015, Journal of Clinical VirologyCitation Excerpt :Of interest, case 5 developed HAV one week after HAV vaccination. This serves as a reminder that post-exposure prophylaxis with HAV vaccine is only 79% effective when administered 1–14 days post-exposure, and may be less efficacious in patients over 40 years old [10–12]. In this instance, she was likely to have been already incubating HAV when vaccination was given.