Renal transplantationCandidateTumours in End-Stage Kidney
Section snippets
Materials and Methods
At our institution, kidney tumors were found in 14 patients with ESKD from January 2002 to December 2006 (Table 1). Before 2002, we were not aware of these cases. We must mention that patients with ESKD are not regularly scheduled for follow-up graphic examinations of kidneys at our institution. The first cases in 2002 were a stimulus for a more active search for these tumours in ESKD. Incidental findings were obtained in 13 cases; in 1 case there were symptoms due to a rupture of a papillary
Results
The male-to-female ratio was 13:1. The mean age was 53.7 ± 10.5 years (range, 40.8–77.9 years). The mean time on dialysis (including potential transplantation) to the diagnosis of tumor was 78 ± 54 months (range, 0–154 months). Kidney tumors were found on CT in 13 patients, including 3 bilateral. In 1 patient who underwent bilateral nephrectomy for uncontrollable hypertension, multiple small tumors were found only in a histological specimen. Thirteen patients underwent nephrectomy, which was
Discussion
Denton et al4 pointed out the frequency of renal tumors in ESKD. At their institution, the majority of patients undergo an ipsilateral native nephrectomy at the time of transplantation. In a group of 260 kidney specimens were found: 33% acquired renal cystic disease (ARCD), 14% renal adenoma, 4.2% RCC, and 0.6% oncocytoma. The majority of RCC (91%) had underlying ARCD and 73% had coexisting papillary adenomas.4
Another question is, how frequent is multifocality and bilaterality of tumors in
References (26)
- et al.
Cancer in patients on dialysis for end-stage renal disease: an international collaborative study
Lancet
(1999) - et al.
Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis
Kidney Int
(2002) - et al.
Renal cell carcinoma in an end-stage kidney of a patient with functional transplant: cytogenetic and molecular genetic finding
Cancer Genet Cytogenet
(1996) - et al.
Renal cell carcinoma in patients with end-stage renal disease: a comparison of clinical significance in patients receiving hemodialysis and those with renal transplant
Urology
(1994) - et al.
Renal cell carcinoma and end stage renal disease
J Urol
(2006) - et al.
Renal cell carcinoma associated with end stage renal disease
J Urol
(2006) - et al.
Renal adenocarcinoma and end stage kidney disease
J Urol
(1987) - et al.
Chromophobe renal cell carcinoma with acquired cystic disease of the kidney in a long term hemodialysis patient
Int J Urol
(2003) - et al.
Renal cell and transitional cell carcinoma in a Japanese population undergoing maintenance dialysis
J Urol
(2005) - et al.
Chromosomal abnormalities in renal cell neoplasms associated with acquired renal cystic diseaseA series of studies by comparative genomic hybridization and fluorescence in situ hybridization
J Pathol
(1999)
Acquired cystic disease of the kidney: a hazard of long-term intermittent maintenance hemodialysis
J Clin Pathol
Renal cystic neoplasms and renal neoplasms associated with cystic renal disease: pathogenetic and molecular links
Adv Anat Pathol
Renal cell carcinoma of end-stage renal disease: an analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification
Mod Pathol
Cited by (40)
Nephron sparing in the management of localized solid renal mass
2023, Bulletin du CancerFrench AFU Cancer Committee Guidelines - Update 2022-2024: management of kidney cancer
2022, Progres en UrologieCitation Excerpt :L’activité physique pourrait réduire le risque de cancer du rein, notamment en réduisant l’obésité et l’hypertension artérielle [4]. Les patients qui ont une insuffisance rénale chronique ont un risque augmenté de développer un cancer du rein (jusqu’à dix fois supérieur à celui de la population générale), avec des atteintes fréquemment bilatérales et/ou multifocales [5,6] (Tableau de recommandation 1). La plupart des tumeurs rénales sont découvertes de manière fortuite sur des échographies ou tomodensitométries (TDM) abdominales prescrites pour d’autres raisons médicales [7].
French ccAFU guidelines - update 2020–2022: management of kidney cancer
2020, Progres en UrologieIntegrated Molecular Analysis of Papillary Renal Cell Carcinoma and Precursor Lesions Unfolds Evolutionary Process from Kidney Progenitor-Like Cells
2019, American Journal of PathologyCitation Excerpt :Connecting all stages is an embryonic developmental theme (identified consistently by all molecular modalities) that points toward a progenitor cell origin for PRCC. PRCC and PA lesions are both common in ESKD.15,84,85 PA accompanies approximately 73% of RCCs in ESKD.86
French ccAFU guidelines – Update 2018–2020: Management of kidney cancer
2018, Progres en Urologie
This work was supported by Czech government research project MSM 0021620819.