Original CommunicationBiological behavior and prognosis of familial papillary thyroid carcinoma
Section snippets
Patients
Between 1987 and 2004, 6,015 patients underwent initial surgical treatment for papillary carcinoma at Kuma Hospital. Of these 6,015 patients, 273 (4.5%) were classified as having familial papillary carcinoma, because they had one or more 1st-degree relatives who underwent surgical treatment for papillary or follicular carcinoma. The criteria for FNMTC in the present study were the same as those reported by Uchino et al.12 Of these 273 patients, 255 (93.4%) belonged to families having 2 affected
Incidence of familial papillary carcinoma
We retrospectively examined the records of 6,015 patients with papillary carcinoma who underwent an initial surgical treatment in Kuma Hospital between 1987 and 2004. As indicated above, 273 patients (4.5%) were diagnosed as having familial papillary carcinoma.
Preoperative evaluation
Size, location, and multicentricity of primary carcinoma and lymph node metastasis were evaluated by ultrasonography for all patients. Of 6,015 patients in our series, 1,722 (29%) were preoperatively diagnosed as multicentric. Lymph node
Discussion
In this study, we demonstrated that DFS and CSS of patients with familial papillary carcinoma were the same as those of sporadic carcinoma patients. This is, however, discrepant with that of a previous study from Japan,12 which reported that familial FNMTC showed a worse DFS. They analyzed patients who underwent surgical treatment between 1946 and 2000, and their follow-up periods averaged longer than 11 years. We enrolled patients who received their initial surgery after 1987, resulting in a
References (20)
- et al.
Risk factors contributing to a poor prognosis of papillary thyroid carcinoma; validity of UICC/AJCC TNM classification and stage grouping
World J Surg
(2007) - et al.
Prognostic significance of extrathyroid extension of papillary thyroid carcinoma: massive but not minimal extension affects the relapse-free survival
World J Surg
(2006) - et al.
Ultrasound-detectable and anatomopathologically-detectable node metastasis in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma
World J Surg
(2005) Familial nonmedullary thyroid carcinoma-the case for genetic susceptibility
J Clin Endocrinol Metab
(1998)- et al.
Familial nonmedullary thyroid cancer
Thyroid
(2005) - et al.
Carcinoma of the thyroid and other diseases of the thyroid in identical twins
Arch Surg
(1955) - et al.
Familial occurrence of differentiated (non-medullary) thyroid cancer
Oncology
(1975) - et al.
Increased risk for nonmedullary thyroid cancer in the first-degree relatives of prevalent cases of nonmedullary thyroid cancer: a hospital-based study
J Clin Endocrinol Metab
(2001) - et al.
Systematic population-based assessment of cancer risk in the first-degree relatives of cancer probands
J Natl Cancer Inst
(1994)
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