Systemic lupus erythematosusUnderstanding the Epidemiology and Progression of Systemic Lupus Erythematosus
Section snippets
Methods
This review is based on publications found through searches of the MEDLINE database for relevant articles using the combination search terms of lupus and (epidemiology, incidence, prevalence, mortality, gender, ethnicity, damage, quality of life). References within these selected reports were also reviewed. We included epidemiological studies of incidence or prevalence that spanned the years 1975 to 2000, and mortality studies of cohorts assembled in 1975 or later. The mortality studies were
Incidence and Prevalence of SLE Around the World
Incidence rates of SLE range from approximately 1 to 10 per 100,000 person-years (Table 1) (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24) and prevalence rates generally range from 20 to 70 per 100,000 (Table 2) (6, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35). In reviewing the available studies, it is important to note that epidemiological studies of SLE may differ by sampling and recruitment methodologies used. The
Discussion
We have reviewed the published literature related to the incidence and prevalence rates of SLE as well as the factors affecting the expression and the intermediate and long-term outcomes of the disease, including mortality risk, organ damage, and health-related quality of life. The disease is overall more frequent among minority population groups around the world and the outcome of the disease is less favorable in these populations. The role of socioeconomic factors in the course and outcome of
Acknowledgments
This article is based on presentations and discussions that took place during the workshop on “Lupus and the Environment: Disease Development, Progression and Flare,” which was held in Washington, DC, September, 2005. The concept for this focused workshop was produced by the Federal Interagency Working Group on Women's Health and the Environment and support was provided by the U.S. Department of Health and Human Services' Office of Women's Health, The National Institute of Environmental Health
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