Original articlePrevalence and Progression of Myopic Retinopathy in Chinese Adults: The Beijing Eye Study
Section snippets
Materials and Methods
The Beijing Eye Study is a population-based prospective cohort study in Greater Beijing. Of 5324 individuals with an age of 40+ years who were eligible, 4439 individuals participated in the baseline study in 2001 (response rate, 83.4%). The mean age was 56.0±10.4 years (range, 40–101 years). In 2006, the study was repeated by inviting all participants from the survey of 2001; 3251 subjects (73.2%) of the 4439 participants of the 2001 study took part. The study was divided into a rural part
Results
Of the 4439 individuals, readable fundus photographs and data on the refractive error were available on 4342 (97.8%). All aphakic and pseudophakic eyes were excluded, so 4319 participants (97.3%; 8484 eyes) remained. On the basis of the questionnaire administered to all study participants, none of those included had undergone refractive surgery. Myopia, which was defined as a myopic spherical equivalent of > −0.50 diopters (D), was present in at least 1 eye of 1191 participants (1980 eyes).
Discussion
Myopic retinopathy, which was found in 2.3%±0.2% of the eyes included in the study, was associated significantly with higher age (P<0.001), worse best-corrected visual acuity (P<0.001), deeper anterior chamber (P = 0.04), larger optic disc (P<0.001), lower prevalence of age-related macular degeneration (P = 0.02; OR 0.90), and greater prevalence of open-angle glaucoma (P<0.001; OR 4.42). The presence of myopic retinopathy was not associated significantly (P>0.20) with body height and weight,
Study Limitations
Potential limitations of our study should be mentioned. The major concern, and a problem inherent to any epidemiologic study, is nonparticipation. The Beijing Eye Study 2006 had a reasonable response rate of approximately 73%, 3251 of the 4439 subjects invited for the follow-up survey (or 61% of the group originally eligible in 2001); however, differences between participants and nonparticipants may have led to a selection artifact and produced bias in the prevalence rates of myopic
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Manuscript no. 2009-1173.
Financial Disclosure(s): The author(s) have made the following disclosure(s): Jost B. Jonas: Consultant for Allergan Inc.; Merck & Co., Inc.; Pfizer Inc.; CellMed AG, Alzenau, Germany; Morphosys AG, Munich, Germany; SOOFT SpA Montegiorgio, Italy; Patent holder with CellMed AG, Alzenau, Germany.
Funded with a grant from the National Key Laboratory Fund, Beijing, China.