Original ArticleRelation of Visual Function to Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis
Section snippets
Subjects
Patients and disease-free control subjects in the MS Vision Prospective Cohort Study,15 an ongoing investigation of visual outcome measures, were invited to participate. Multiple sclerosis was diagnosed by standard clinical and neuroimaging criteria.42 Disease duration, disease-specific therapies (e.g., immunomodulatory agents) and their duration, and MS disease phenotype (relapsing–remitting, secondary progressive, primary progressive) were ascertained for each MS patient. Patients with
Results
Ninety patients with MS (180 eyes) and 36 disease-free controls (72 eyes) underwent vision testing and OCT imaging. Demographic and clinical characteristics are presented in Table 1. Because patients and disease-free controls in this convenience sample differed with respect to age, statistical models used for analyses included age as a covariate. Multiple sclerosis patients in our cohort were similar to the United States MS population with regard to age, gender, and race (88% Caucasian). Eighty
Discussion
Results of these investigations demonstrate that low-contrast letter acuity and contrast sensitivity, the two most promising candidate visual outcome measures for MS, correlate well with RNFL thickness. Although eyes with a history of acute optic neuritis (MS ON eyes) demonstrate the greatest reductions in RNFL thickness, MS non-ON eyes are also abnormal (including fellow eyes of MS patients with a history of unilateral optic neuritis), supporting the occurrence of anterior visual pathway
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Manuscript no. 2005-476.
Supported in part by the National Institutes of Health, Bethesda, Maryland (grant nos.: R01 EY 013273, R01 EY 014993) (LJB); National Multiple Sclerosis Society, New York, New York (grant nos.: RG 3208-A-1, RG 3428A2/1, PP1115) (LJB); McNeill Foundation, Philadelphia, Pennsylvania (LJB); and Doris Duke Foundation, New York, New York (JBF).
No conflicting relationships exist.