Case reportProgressive enlargement of acquired retinal astrocytoma in 2 cases☆
Section snippets
Case 1
In February 1998, a 14-year-old Caucasian girl was seen with 2 months of blurred vision in her right eye. The visual acuity was 20/30 in the right eye and 20/20 in the left eye. The left eye was normal. The right eye demonstrated a white gelatinous retinal tumor with epipapillary involvement, measuring 4.0 mm × 3.0 mm in base and 2.5 mm in thickness (Fig 1). There were no dilated feeder vessels, exudation, or subretinal fluid. The lesion was surrounded by dramatic preretinal fibroglial tissue
Discussion
Retinal astrocytic tumors are uncommon and are generally subdivided into 1 of 3 types, including astrocytic hamartoma, acquired astrocytoma, and retinal gliosis.1, 2, 20 Retinal gliosis is typically a reactive process, usually occurring after posterior segment inflammation or infection.20 If focal or nodular, the process appears as a dense white mass within or superficial to the retina. Signs of previous retinal inflammation and retinal pigment epithelial proliferation are usually present. If
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2016, Survey of OphthalmologyCitation Excerpt :Nonetheless, a needle biopsy in the context of phthisis bulbi harboring a solid tumor in the vitreous cavity should be seriously considered as a first diagnostic maneuver. Although most astrocytic masses of the inner retina are hamartomatous and often detected in tuberous sclerosis and less frequently in neurofibromatosis type-1, truly neoplastic astrocytomas with inexorable, destructive growth reaching a considerable size and sometimes entirely filling the globe have been described.25,35,50,64,65,69 They may exhibit intraretinal and subretinal exudates not seen in the stationary hamartomas, but tend not to provoke the extensive osseous metaplasia of the pigment epithelium that characterizes the reactive tumoral gliotic masses associated with phthisis bulbi.
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2015, Revista Mexicana de Oftalmologia
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Manuscript no. 230022.
Supported by the Rosenthal Award of the Macula Society (CLS), the Eye Tumor Research Foundation, Philadelphia, Pennsylvania (CLS), the Paul Kayser International Award of Merit in Retina Research, Houston, Texas (JAS), and the Noel T. and Sara L. Simmonds Endowment for Ophthalmic Pathology, Wills Eye Hospital, Philadelphia, Pennsylvania (RCE).