Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity
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Graphical abstract
Keywords
Sodium channel
Use-dependence
Myotonia
Membrane hyperexcitability
Tocainide derivative
Mexiletine
Abbreviations
TRR
time of righting reflex
9-AC
anthracene-9-carboxylic acid
SAR
structure-activity relationship
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© 2017 The Authors. Published by Elsevier Ltd.