Neuron
Volume 56, Issue 3, 8 November 2007, Pages 415-417
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A Histone Deacetylase Regulates Addiction

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Epigenetic modification of chromatin has been proposed to translate environmental stimuli into persistent “cellular memories.” Recent studies suggest that epigenetic pathways regulate long-term behavioral adaptation in the nervous system. In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine.

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