ReviewInternalization and Mechanism of Action of Clostridial Toxins in Neurons
Section snippets
INTRODUCTION
Many pathogenic bacteria produce protein toxins that act inside cells. These toxins bind to the cell surface, become internalized in vesicular compartments, and translocate their catalytic subunit into the cytosol, where they exert their toxic activity by enzymatically modifying a protein substrate (Montecucco et al., 1994). Tetanus (TeNT) and botulinum (BoNT) neurotoxins, endowed with a metalloprotease activity, belong to this group of bacterial toxins. They are released from bacteria as
Acknowledgements
Work in our laboratory is supported by Telethon GGP04196, by FISR-CNR Neurobiotecnologia 2003, by FIRB (RBNE01RHZM), by MIUR-CNR Functional Genomics and PRIN-MIUR 2003 055110-002.
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