Response to OpinionMapping the road to resilience: Novel math for the study of frailty
References (10)
MR spectroscopy of metabolic disorders
Neuroimaging Clin. N. Am.
(2006)- et al.
The evolution of developmental mechanisms
Dev. Biol.
(2003) - et al.
Modeling and simulation in signal transduction pathways: a systems biology approach
Biochimie
(2006) - et al.
Stimulusresponse paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty
Mech. Ageing Dev
(2008) - et al.
Statistical tools for linkage analysis and genetic association studies
Expert. Rev. Mol. Diagn.
(2005)
Cited by (35)
The challenge of clinical complexity in the 21st century: Could frailty indexes be the answer?
2017, Revista Espanola de Geriatria y GerontologiaEnergetic interventions for healthspan and resiliency with aging
2016, Experimental GerontologyCitation Excerpt :Common challenges to physiologic human resiliency include surgical stress, burns, bone fractures, metabolic duress (e.g. obesity, metabolic syndrome), chemotherapeutic regimens, toxins, infections, immobility and bed rest, among others. The concept of physiologic resiliency as it relates to aging, has been proposed by a number of groups in a variety of contexts (Ferrucci et al., 2008; Sorrell, 2008; Varadhan et al., 2008; Whitson et al., 2008; Wook Yoo et al., 2015), and is recognized to decline with age due in part to a progressive accumulation of molecular and cellular damage and weakening of interactions among multiple physiologic regulatory functions, leading to a loss of physiologic reserves and impaired ability to restore homeostasis and function. Importantly, the gradual loss of resiliency with age contributes to, and may underlie the onset of aging-related conditions, including chronic disease, multimorbidity, frailty syndrome, and death (Bergman et al., 2007; Fabbri et al., 2015; Ferrucci et al., 2008; Fried et al., 2001; Piggott et al., 2015; St Sauver et al., 2015) (Fig. 1).
Frailty: An Emerging Public Health Priority
2016, Journal of the American Medical Directors AssociationCitation Excerpt :Recently, a study by Lee and colleagues27 reported specific characteristics significantly associated with negative (older age, history of cancer, hospitalization events, chronic obstructive pulmonary disease, cerebrovascular disease, osteoarthritis) and positive (higher cognitive function, absence of diabetes, higher socioeconomic status, and no history of cerebrovascular disease) change in frailty status. Recently, the concept of “resilience” (the individual's ability to adapt in the face of stresses and adversities) has become increasingly used in the field of frailty.28 A frail individual with low resilience is more likely to fall into a disabling cascade and quickly develop negative outcomes, whereas high resilience may be protective and facilitate maintenance of health status.
Cognitive frailty, a novel target for the prevention of elderly dependency
2015, Ageing Research ReviewsCitation Excerpt :When people age, the emergence of abnormalities in three or more systems (e.g., pathophysiological modifications caused by cardiovascular and pulmonary diseases and diabetes) may accelerate the depletion of physiological reserves and initiate frailty-related homeostatic failure. As a consequence, homeostasis becomes less likely to be sufficient for the maintenance and repair of the aging body, which in turn becomes vulnerable regarding stress responses, such that even minor stress events can lead to the above hormesis process and disproportionate changes in health (Clegg et al., 2013; Fried et al., 2001, 2009; Varadhan et al., 2008; Ferrucci et al., 2008; Kalyani et al., 2012; Chaves et al., 2008). Genetic and environmental stressors may cause dysfunctions in susceptible neurons of specific brain systems (e.g., medial temporal lobe system and fronto-striatal system) and the decline of structural (e.g., number of neurons and synapses) and functional reserves.
Successful aging and indicators of frailty in the elderly. Octabaix Study
2014, Atencion Primaria