Elsevier

The Journal of Pediatrics

Volume 232, May 2021, Pages 287-289.e4
The Journal of Pediatrics

Brief Reports
Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

https://doi.org/10.1016/j.jpeds.2021.01.027Get rights and content

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019–compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.

Keywords

SARS-CoV-2
antigen test
PCR
COVID-19

Abbreviations

Ag
Antigen
COVID-19
Coronavirus disease 2019
CT
Cycle threshold
NLR
Negative likelihood ratio
NPS
Nasopharyngeal sample
PLR
Positive likelihood ratio
RT-PCR
Reverse-transcriptase polymerase chain reaction
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2

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∗Contributed equally.

Supported by a specific Research Grant of the Spanish Society of Pediatrics (Asociación Española de Pediatría). This study was funded by project PI20/00095, from the Instituto de Salud Carlos III (Ministry of Economy, Industry and Competitiveness), and cofounded by the European Regional Development Funds. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. CDG is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER (Contrato Río Hortega CM19/00015). The authors declare no conflicts of interest.

List of additional members of the working group available at www.jpeds.com (Appendix).

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