The Journal of Allergy and Clinical Immunology: In Practice
Original ArticleCor a 14, Hazelnut-Specific IgE, and SPT as a Reliable Tool in Hazelnut Allergy Diagnosis in Eastern Mediterranean Children
Section snippets
Study population
Children with IgE-mediated hazelnut allergy being followed up at the Division of Pediatric Allergy in Hacettepe University between January 2011 and January 2014 participated in the study. All parents were questioned diligently to determine reliable cause and effect relationships between the ingestion of hazelnut and the presentation of symptoms. Data collected included age, gender, baseline symptoms, sIgE levels, SPT wheal diameters, other food allergies, and associated atopic diseases.
The
Results
A total of 64 children (70.3% boys) with a median (IQR) age of 3.4 (2.1-7.2) years participated in the study (Table I). There was a male predominance in the children and most of them had atopic dermatitis in their clinical history. DBPCFC tests were performed in 56 children to determine the clinical reactivity to hazelnut. Eight children were included in the study without performing food challenge on account of experiencing anaphylaxis within the last 12 months after accidental hazelnut intake.
Discussion
This study is a comprehensive evaluation of hazelnut allergy combining the previous methods consisting of SPT and sIgE to natural hazelnut extract and the new recombinant and natural hazelnut allergens including Cor a 1, Cor a 8, Cor a 9, and Cor a 14 in hazelnut-reactive versus hazelnut-tolerant and pollen-sensitive versus non–pollen-sensitive subjects. In this study, we determined optimal cutoff values and probability curves of natural hazelnut extract sIgE, SPT wheal diameter, and IgE to Cor
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This study was supported by the Scientific Research Unit (SRU) of Hacettepe University, number 012 D11 101 005. SRU had no involvement in the study design, data analysis and interpretation, writing the report, and decision to submit the article for publication.
Conflicts of interest: The authors declare that they have no relevant conflicts.