Asthma and lower airway diseaseAssessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma
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This study was funded by GlaxoSmithKline (GSK ID: MEA115666; ClinicalTrials.gov number: NCT01691859).
Disclosure of potential conflict of interest: S. Khatri reports being an investigator in clinical trials in relation to GlaxoSmithKline and Boston Scientific, for which her institution is compensated for time related to the study. W. Moore reports receiving research grants from GlaxoSmithKline, AstraZeneca, Boehringer Ingelheim, Novartis, Pearl Therapeutics, Sanofi Regeneron, and the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI), and has been an advisory board consultant for AstraZeneca and Sanofi Regeneron. P. G. Gibson reports receiving personal fees from AstraZeneca, GlaxoSmithKline, and Novartis and a research grant from GlaxoSmithKline and the National Health and Medical Research Council (NHMRC). R. Leigh reports receiving honoraria and speakers' fees from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Novartis, and TEVA; his institution has also received research funding from AstraZeneca, GlaxoSmithKline, MedImmune, Novartis, and Sanofi for clinical trials in which he was a site investigator. A. Bourdin reports receiving personal fees, research grants, and nonfinancial support from GlaxoSmithKline; personal fees and nonfinancial support from AstraZeneca and Novartis; research grants from MSD; research grants and personal fees from Actelion; and personal fees and nonfinancial support from Chiesi. J. Maspero reports attending focus groups and boards for AstraZeneca and receiving personal fees from Novartis, AstraZeneca, GlaxoSmithKline, Sanofi, and Uriach. M. Barros reports receiving honoraria from Boehringer Ingelheim and Grifols for lectures and Advisory boards and has been involved as Principal Investigator in clinical trials for GlaxoSmithKline, Pearl Therapeutics, Sanofi Aventis, and Chiesi. R. Buhl reports personal fees from AstraZeneca, Chiesi, Teva, and Cipla; grants and personal fees from Boehringer Ingelheim, Novartis, and Roche; and grants from GlaxoSmithKline, all of which are outside the submitted work. P. Howarth, F. C. Albers, E. S. Bradford, M. Gilson, R. G. Price, and S. W. Yancy are all employees of GlaxoSmithKline and hold stocks/shares in GlaxoSmithKline. H. Ortega is a former employee of GlaxoSmithKline and holds stocks/shares in GlaxoSmithKline.
Anonymized individual participant data and study documents can be requested for further research from www.clinicalstudydatarequest.com
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Dr Ortega is currently affiliated with Gossamer Bio, San Diego, Calif.