Journal of American Association for Pediatric Ophthalmology and Strabismus
Major ArticleLongitudinal reproducibility of optical coherence tomography measurements in children
Section snippets
Methods and Materials
This study was approved by the Duke Health System Institutional Review Board and complied with the requirements of the Health Insurance Portability and Accountability Act. Written informed consent was obtained for each subject from the legal guardian. Verbal assent was obtained from all subjects. Additional written assent was obtained from each child who was at least 12 years of age.
The Stratus OCT (Carl Zeiss, Dublin, CA) was used to obtain fast macular and fast RNFL 3.4 thickness protocols.8
Results
The first study setting included 8 normal eyes of 8 children. The average age at initial examination was 9.1 ± 2.3 years. The average time between the first and second visits was 0.2 years; between the first and third visits, 3.3 years. The ICC for total macular volume and average RNFL within visits showed very good reproducibility (0.91-0.98, Tables 1 and 2).
At the initial visit, the average axial length was 23.5 mm (range, 22.3-24.1), the average total macular volume was 7.0 mm3 (95%
Discussion
Among children with normal eyes as well as those with suspected or known glaucoma, global Stratus OCT measurements of total macular volume and average RNFL thickness were reproducible over several years. Among normal eyes, over an average of 3 years, there was a statistically significant increase in average axial length measurements; however, the change in average RNFL thickness as average axial length increased was not statistically significant. Although previous cross-sectional studies have
Literature Search
The authors searched PubMed (MEDLINE) for English-language only articles for the period 1946 to 2012 using combinations of the following search terms: pediatric glaucoma, OCT OR optical coherence tomography, reproducible OR reproducibility.
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2019, American Journal of OphthalmologyCitation Excerpt :pRNFL global thickness showed a weak negative correlation with axial length in multiple regression analysis. Previous studies in children have shown no relationship between global pRNFL thickness and axial length in some29–31 and a negative correlation in others.32,33 Aykut and associates33 found that this relationship disappeared when a correction was applied for the effect of ocular magnification as it relates to axial length.
Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years of Age
2019, American Journal of OphthalmologyCitation Excerpt :Axial length has been reported to have an inverse relationship with optic disc parameters, RNFL thickness, and macular thickness.26,47–50 Similar to Prakalapakorn and colleagues,35 we did not find a relationship between peripapillary RNFL and GCC thickness at the macula. While there are developmental changes at the level of the fovea, optic nerve, and axial length during early life, we have found a stable macular GCC volume and peripapillary RNFL thickness.
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2019, Handbook of Pediatric Retinal OCT and the Eye-Brain ConnectionEmerging Applications of Optical Coherence Tomography in Pediatric Optic Neuropathies
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Dr. Prakalapakorn is supported by NIH EY016333 and an unrestricted grant from Research to Prevent Blindness to the Duke Eye Center.