Immunity
Volume 33, Issue 4, 29 October 2010, Pages 504-515
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Review
Immunologic Basis of Vaccine Vectors

https://doi.org/10.1016/j.immuni.2010.10.004Get rights and content
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Efforts to make vaccines against infectious diseases as well as immunotherapies for cancer, autoimmune diseases and allergy have utilized a variety of heterologous expression systems, including viral and bacterial vectors, as well as DNA and RNA constructs. This review explores the immunologic rationale and provides an update of insights obtained from preclinical and clinical studies of such vaccines.

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