Original pre-clinical scienceInhibition of renin angiotensin aldosterone system causes abrogation of obliterative airways disease through inhibition of tumor necrosis factor-α–dependant interleukin-17
Section snippets
Materials and methods
All experiments in this study were performed in compliance with the guidelines of the Institutional Laboratory Animal Care and Use Committee of Washington University School of Medicine (protocol 20070121).
ACEI and ARB abrogate the development of OAD lesions after administration of antibodies to MHC class I
To determine the role of alloimmunity in development of OAD, we previously developed a murine model for OAD. At 30 days after intrabronchial administration of anti-MHC class I antibody (anti–H-2Kb), classic OAD lesions developed in the lungs of C57Bl/6 mice, as evidenced by the cardinal features, namely, cellular infiltration around the vessels, bronchioles, epithelial hyperplasia, and fibrosis. However, similar administration of C1.18.4 control antibody of the same isotype in the control
Discussion
Although the pathogenesis of BOS is not fully defined, several risk factors have been associated with the development of chronic rejection, including acute rejection, cytomegalovirus, gastroesophageal reflux disease, and HLA mismatches.20 Previous studies from our laboratory and others have proposed a role for antibodies to self-antigens collagen V and K-α1T in the pathogenesis of BOS after LTx.9, 19, 21 Alloimmune-mediated development of de novo autoimmunity to self-antigens appears to have a
Disclosure statement
This work was supported by National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)/National Institute of Allergy and Infectious Diseases (NIAID) grant HL092514−01A2 and the BJC Foundation to T.M. and NIH/NHLBI grant T32 HL007312 to J.W.
The authors thank Billie Glasscock for her help in preparing this manuscript.
None of the authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts
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JW and VT are the co-first authors of this manuscript.