Theories, mechanisms, and models of alcoholic chronic pancreatitis
Section snippets
Observations and hypotheses in human alcoholic chronic pancreatitis
Chronic pancreatitis has been defined as irregular sclerosis of the pancreatic gland with destruction and loss of exocrine parenchyma (which can be focal, segmental, or diffuse), dilation of the ductal system associated with strictures or stones, or inflammatory cell infiltration with islets appear to be spared somewhat compared with acini [17]. Chronic pancreatitis is a syndrome of progressive inflammatory destruction and fibrosis in which all histologic features may be seen in all etiologies
Animal models for alcoholic chronic pancreatitis
The use of animal models has been invaluable in helping to understand critical factors and mechanisms in many human diseases. Although animal models do not reproduce all of the features of alcoholic pancreatitis in people, they are very useful for understanding specific mechanisms of injury, inflammatory response, and adaptation. There are basically two rat models that have been used widely in alcohol studies of liver disease and adapted to the study of pancreatic diseases: the Lieber-DeCarli
References (97)
- et al.
Chronic pancreatitis: diagnosis, classification, and new genetic developments
Gastroenterology
(2001) - et al.
Recurrent acute pancreatitis: an algorithmic approach to identification and elimination of inciting factors
Gastroenterology
(2001) Pathogenesis of alcohol-induced chronic pancreatitis: facts, perceptions, and misperceptions
Surg Clin North Am
(2001)- et al.
Course of alcoholic chronic pancreatitis: a prospective clinicomorphological long-term study
Gastroenterology
(1996) - et al.
The natural history of pain in alcoholic chronic pancreatitis
Gastroenterology
(1999) - et al.
Animal models in alcoholic pancreatitis—what can we learn?
Pancreatology
(2002) - et al.
Pancreatic stone protein (lithostathine), a physiologically relevant pancreatic calcium carbonate crystal inhibitor?
J Biol Chem
(1997) - et al.
Hereditary pancreatitis: a model for inflammatory diseases of the pancreas
Best Pract Res Clin Gastroenterol
(2002) - et al.
Pancreatic stone protein. II. Implication in stone formation during the course of chronic calcifying pancreatitis
Gastroenterology
(1985) - et al.
Renaming pancreatic stone protein as lithostathine
Gastroenterology
(1990)
Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine
Gastroenterology
Both ethanol and protein deficiency increase messenger RNA levels for pancreatic lithostathine
Life Sci
Lithostathine, the presumed pancreatic stone inhibitor, does not interact specifically with calcium carbonate crystals
J Biol Chem
Chronic ethanol administration decreases rat pancreatic GP2 content
Biochim Biophys Acta
Effect of chronic ethanol ingestion on pancreatic protein synthesis
Biochim Biophys Acta
Stimulation of protein synthesis in isolated pancreatic acini from chronically ethanol-fed rats is due to alterations in post-transcriptional regulation
Biochim Biophys Acta
Metabolism of ethanol by rat pancreatic acinar cells
J Lab Clin Med
Nonoxidative metabolism of ethanol in the pancreas; implication in alcoholic pancreatic damage
Biochem Pharmacol
Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol
Gastroenterology
Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats
Gastroenterology
Ultrastructure of the rat exocrine pancreas after long term intake of ethanol
Gastroenterology
Identification, culture, and characterization of pancreatic stellate cells in rats and humans
Gastroenterology
Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells
Gastroenterology
Alcohol-induced pancreatic injury
Best Pract Res Clin Gastroenterol
Pancreatic acinar cell function and morphology in rats chronically fed an ethanol diet
Gastroenterology
Chronic ethanol administration causes oxidative stress in the rat pancreas
J Lab Clin Med
Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide
Gastroenterology
The effect of ethanol on pancreatic enzymes—a dietary artifact?
Biochim Biophys Acta
Acute pancreatitis and bile duct lesions in rat induced by dibutyltin dichloride
Exp Pathol
Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice
Gastroenterology
Chronic pancreatitis
N Engl J Med
Acute pancreatitis
N Engl J Med
Pancreatitis: acute and chronic
Disease of the pancreas
Does acute alcoholic pancreatitis exist without pre-existing chronic pancreatitis?
Scand J Gastroenterol
Lecons de Physiologie Experimentale
Experimental models of pancreatitis
Ann Acad Med Singapore
Experimental models of acute pancreatitis
Int J Pancreatol
Experimental models of acute pancreatitis and their clinical relevance
A review: acute and chronic effects of ethanol and alcoholic beverages on the pancreatic exocrine secretion in vivo and in vitro
Alcohol Clin Exp Res
Pancreatitis: symposium of Marseille, 1963
Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis
Br J Surg
Chronic relapsing pancreatitis
Gastroenterology
Progression of alcoholic acute to chronic pancreatitis
Gut
Repetitive cerulein-induced pancreatitis and pancreatic fibrosis in the rat
Pancreas
A morphological analysis of 57 resection specimens and 9 autopsy pancreata
Pancreas
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
Nat Genet
Lithostathine messenger RNA expression in different types of chronic pancreatitis
Mol Cell Biochem
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Various aspects of this work were supported by National Institutes of Health grants DK50236/AA10885 (DCW), DK061451 (DCW), a Veterans Administration Merit Review (DCW) and a grant from the Turkish Gastroenterology Foundation (NO).