Original articleClinical endoscopyEUS is still superior to multidetector computerized tomography for detection of pancreatic neuroendocrine tumors
Section snippets
Patients and methods
Our prospective pathology database was queried for PNETs that were resected at Johns Hopkins Hospital (JHH) from May 1984 to August 2009. Patients with PNETs that were found incidentally in pancreatic specimens resected for other primary pathologies and those who did not undergo CT examination at JHH were excluded from the study. At our center, 4-detector CT was introduced in 1990, 16-detector in mid-1996, and 64-detector in mid-2002. The study was approved by the Institutional Review Board for
Results
During the study period, 385 patients with ≥1 PNET underwent surgical resection at our institution. After excluding 40 PNETs that were found incidentally in surgical specimens resected for other primary pancreatic pathologies (most commonly pancreatic adenocarcinoma) and 128 without a JHH CT, we studied 217 patients (Fig. 1) with 231 PNETs (female, 52%; mean age, 56 years; mean tumor diameter, 32.7 mm ± 30 mm). The mean size of insulinomas was significantly smaller than that of noninsulinomas
Discussion
The present study reports a large radiologic and EUS series of pathologically proven PNETs. During a 26-year period, 385 patients with ≥1 PNET underwent resection at our hospital. We excluded all patients who did not undergo CT examination at JHH to ensure homogeneity of the data. Our study cohort included 217 patients with 231 PNETs: 173 (74.9%) nonfunctional PNETs and 58 (25.1%) functional PNETs. Insulinomas accounted for the majority (60.3%) of functional PNETs. In most older series,
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DISCLOSURE: All authors disclosed no financial relationships relevant to this publication.
If you would like to chat with an author of this article, you may contact Dr Canto at [email protected].
See CME section; p. 798.