Original Article
Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review

https://doi.org/10.1016/j.gassur.2004.06.012Get rights and content

Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.

Key words

PTH-rP
pancreatic endocrine neoplasm
hypercalcemia

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