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Parents with bipolar disorder: Are disease characteristics good predictors of psychopathology in offspring?

Published online by Cambridge University Press:  05 September 2012

M. Garcia-Amador ,
E. de la Serna ,
M. Vila ,
S. Romero ,
M. Valenti ,
V. Sánchez-Gistau ,
A. Benabarre ,
E. Vieta  and
J. Castro-Fornieles
M. Garcia-Amador*
Affiliation:
Child and Adolescent Psychiatry Department, CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, Madrid, Spain
E. de la Serna
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain
M. Vila
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain
S. Romero
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain
M. Valenti
Affiliation:
Bipolar Disorders Program, Psychiatry Department, Hospital Clinic Universitari, IDIBAPS, Barcelona, Spain
V. Sánchez-Gistau
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain
A. Benabarre
Affiliation:
Bipolar Disorders Program, Psychiatry Department, Hospital Clinic Universitari, IDIBAPS, Barcelona, Spain
E. Vieta
Affiliation:
Bipolar Disorders Program, Psychiatry Department, Hospital Clinic Universitari, IDIBAPS, Barcelona, Spain Department of Psychiatry and Clinical Psychology, University of Barcelona, Barcelona, Spain
J. Castro-Fornieles
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain Department of Psychiatry and Clinical Psychology, University of Barcelona, Barcelona, Spain
*
⁎Corresponding author. Tel.: +34 915 868 133; fax: +34 914 265 004. E-mail addresses: mgarcia@iisgm.com, margarciamador@gmail.com (M. Garcia-Amador).
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Abstract

Purpose

To investigate rates of psychopathology in the offspring of subjects with bipolar disorder (BP-offspring) compared to the offspring of healthy subjects (HC-offspring) in a Spanish sample and to study possible predictors of psychopathology in BP-offspring.

Subjects

Fifty BP-offspring from 36 families and 25 HC-offspring from 25 families.

Methods

Psychopathology was compared in BP-offspring and HC-offspring. Factors associated with DSM-IV axis I disorders in BP-offspring were analyzed using logistic regression.

Results

Half of BP-offspring fulfilled the diagnostic criteria for at least one axis I disorder with attention-deficit/hyperactivity disorder (30%), anxiety disorders (14%) and affective disorders (10%) as the most frequent. After controlling for having more than one sibling in the study, the odds ratio for BP-offspring presenting an axis I disorder was 15.02 when a biological parent had bipolar disorder with a lifetime history of psychotic symptoms and 3.34 when one parent had bipolar II disorder. Moreover, a higher Global Assessment of Functioning score in the biological co-parent was associated with a significantly lower frequency of axis I disorders in BP-offspring.

Discussion and conclusions

Psychopathology in BP-offspring should be routinely assessed, with special emphasis on children from parents with specific disease characteristics (psychosis, BP II disorder) in order to establish an early diagnosis and appropriate interventions.

Keywords

Adolescent psychiatryBipolar disorderPsychosisQuality of carePsychiatry in Europe
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 4 , May 2013 , pp. 240 - 246
Copyright
Copyright © European Psychiatric Association 2012

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