NotesClinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem
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2020, International Journal of Antimicrobial AgentsCitation Excerpt :In 2010, the Clinical and Laboratory and Standards Institute (CLSI) lowered susceptibility breakpoints for meropenem, imipenem and ertapenem to reduce the prevalence of organisms harbouring carbapenemases deemed ‘susceptible’ by contemporary breakpoints [14,15]. This action was spurred, in part, by reports of clinical failures in patients treated with carbapenems who were infected with ‘susceptible’ carbapenemase-producing Enterobacteriaceae [16,17]. Pharmacokinetic studies, however, suggest that contemporary dosing strategies should provide adequate exposures for minimum inhibitory concentrations (MICs) relative to the current breakpoints [14].
Carbapenem-resistant Enterobacteriaceae: An emerging bacterial threat
2019, Seminars in Diagnostic Pathology
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Authors contributed equally to the work.
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