Explaining delusions of control: The comparator model 20 years on☆
Highlights
► Delusions of control are associated with problems in predicting the consequences of action. ► Similar failures of prediction might explain other positive symptoms of schizophrenia. ► There is a role for dopamine in the response to prediction errors. ► New paradigms are needed so that we can study thoughts as well as actions.
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Cognitive load decreases the sense of agency during continuous action
2023, Acta PsychologicaThe sense of agency for brain disorders: A comprehensive review and proposed framework
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The authors speculated that this “hyper-binding” effect in schizophrenia was due to impairments in predicting the consequences of self-initiated actions. Indeed, future work supported this claim, describing either an impaired or absent forward model of motor control (Frith, 2012). Accordingly, one study found significant cortical thinning in the SMA of schizophrenic patients (Massey et al., 2017).
Reduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis
2021, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :CDs represent the putative neural mechanism responsible for distinguishing between environmental and self-generated stimuli (so-called “self-monitoring”) (Ford and Mathalon, 2019). In psychosis, disturbances in CDs are hypothesized to underlie the false attribution to the outer world of internally generated percepts and thoughts, which could explain symptoms, including hallucinations, delusions (Feinberg, 1978; Frith, 1987; Frith, 2012), and self-disorders (Nelson et al., 2014). Intriguingly, in our patients' group, we reported an association between the reduced intrinsic ability of the motor area to generate beta-2 frontal oscillations, assessed by TMS-EEG, and the severity of positive symptoms (Fig. 3).
Nigrostriatal dopamine signals sequence-specific action-outcome prediction errors
2021, Current Biology
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This article is part of a special issue of this journal on Beyond the Comparator Model.